Skin grafts in nude mice. 2. Rat skin grafts in nude mice of three genetic backgrounds (BALB-c, C3H, C57-BL). The effects after preparation by thymus grafts.
Skin grafts in nude mice. 2. Rat skin grafts in nude mice of three genetic backgrounds (BALB-c, C3H, C57-BL). The effects after preparation by thymus grafts.
复制标题
裸鼠皮肤移植。
DOI：
10.1111/j.1699-0463.1974.tb03830.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
J. Rygaard
中科院分区：
文献类型：
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作者：
J. Rygaard
三种遗传背景BALB/c、C3 H和C57/BL中的每一种的裸小鼠容易接受来自近交系Fischer品系大鼠和其他大鼠品系的皮肤异源移植物。来自相同供体的第二组移植也很容易接受。在所有情况下，移植物均顺利，移植物的最终外观与供体品系的正常动物相同。这一现象与接受同种异体移植的类似裸鼠中观察到的情况形成强烈对比。同种异体移植物的接受延迟，虽然最终接受率几乎为100%，但许多移植物在接受过程中出现了内源性损伤。这种损害表现为许多病例中簇状不规则毛发生长，以及移植皮肤裸露萎缩，尽管有活力。另一个明显的对比是，同种异体移植在裸鼠体内没有引起细胞毒性抗体反应，而接受异种移植的裸鼠血清中细胞毒性抗体滴度是中等到高的。嫁接赋予了异种移植排斥的能力。
Nudemice of each of the three genetic backgrounds BALB/c, C3H, and C57/BL readily accept skin heterotransplants from inbred Fischer strain rats and other rat strains. Second set transplants from the same donors are also readily accepted. In all instances graft take was uneventful, and the final appearance of grafts was as in normal animals of the donor strain. This event contrasts strongly with that observed in similarnudemice receiving allotransplants. Allograft take was delayed, and although ultimate acceptance was virtually 100 per cent, many grafts evidenced endogenous damage occurring during the acceptance process. This damage was manifested by tufted irregular hair growth in many cases, and by bare atrophic, though vital, areas of graft skin. Also strikingly contrasting were the findings that allografting innudemice excited no cytotoxic antibody response, while cytotoxic antibody titres in serum ofnudemice receiving heterotransplants were moderate to high. Thymus grafting confers capacity for heterograft rejxsection.