Fixation of natural furanoeremophilane by Diels-Alder reaction
Fixation of natural furanoeremophilane by Diels-Alder reaction
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DOI：
10.1246/bcsj.80.966
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发表时间：
2007-05-15
影响因子：
4
通讯作者：
Kuroda, Chiaki
中科院分区：
文献类型：
--
作者：
Iida, Kazunori;Mitani, Makoto;Kuroda, Chiaki
以n-乙基和n-苯基马来酰亚胺为亲二酚，制备了相应的立体异构体加合物，研究了亲呋喃-6 - β -醇（petasalbin）及其合成类似物4-羟基-4,5,6,7-四氢苯并呋喃的Diels-Alder反应。将马甲酰亚胺加入到巨型马甲酰亚胺粗提液中，得到了马甲酰亚胺与马甲酰亚胺的加合物。通过该方法估计，乳酸菌提取物中不稳定的呋喃嗜氧菌-10 β -醇的含量大于32%。
Diels-Alder reaction of furanoeremophilan-6 beta-ol (petasalbin) and its synthetic analogue, 4-hydroxy-4,5,6,7-tetrahydrobenzofuran, was studied using N-ethyl- and N-phenylmaleimides as the dienophiles, affording corresponding adducts as mixtures of stereoisomers. The adduct of petasalbin and maleimide was also obtained when the latter compound was added to a crude extracted solution of Petasites japonicus var. giganteus. By using this method, it was estimated that the contents of unstable furanoeremophilan-10 beta-ol in L. eymbulifera is more than 32% of the extract.