Molecular aspects of esophageal squamous cell carcinoma carcinogenesis
Molecular aspects of esophageal squamous cell carcinoma carcinogenesis
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DOI：
10.1590/s0004-28032003000400011
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发表时间：
2003-12-01
影响因子：
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通讯作者：
Cecconello, Ivan
中科院分区：
文献类型：
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作者：
Lehrbach, Dárcio Matenhauer;Nita, Marcelo Eidi;Cecconello, Ivan
背景-人类食管癌的发展是一个多步骤、渐进的过程。该过程的早期指标是食管上皮细胞形态上的增殖增加，包括基底细胞增生、发育不良、原位癌和晚期食管鳞状细胞癌。细胞水平的肿瘤发生过程与细胞增殖、分化的控制紊乱以及细胞的受控死亡（凋亡）有关。大多数癌细胞含有与这些过程的控制相关的遗传改变，包括转录因子和凋亡相关蛋白。目的 - 在这篇综述中，讨论了该食管肿瘤亚型的遗传图谱的当前知识，重点关注开发食管鳞状细胞癌临床治疗新工具的潜力。结论 - 分子生物学领域的进步使我们对食管癌变过程有了更深入的了解。理想情况下，这些知识应该转化为癌症患者的益处。因此，更好地了解癌发生过程中的分子变化有望改善肿瘤控制和预防，也可能导致更好的疾病管理。
Background - The development of human esophageal cancer is a multistep, progressive process. An early indicator of this process is an increased proliferation of esophageal epithelial cells morphologically including basal cell hyperplasia, dysplasia, carcinoma in situ and advanced esophageal squamous cell carcinoma. The process of tumorigenesis at cellular level is related to disorders of the control of cell proliferation and differentiation and controlled cell death (apoptosis). Most of cancer cells contain genetic alterations related to the control of these processes, including transcription factors and apoptosis related proteins. Aim - In this review, the current knowledge of the genetic profile of this subtype of esophageal tumor is discussed, focusing on the potential of the development of novel tools for clinical management of esophageal squamous cell carcinoma. Conclusions - The advances in the field of molecular biology have let us to deeper our knowledge of the process of carcinogenesis of esophagus. Ideally, this knowledge should be translated in benefits for patients suffering from cancer. Thus, better understanding of molecular alterations during carcinogenesis is expected to improve tumor control and prevention and also may lead to better disease management.