Naloxone increases the response of growth hormone and prolactin to stimuli in obese humans
Naloxone increases the response of growth hormone and prolactin to stimuli in obese humans
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纳洛酮可增加肥胖人群生长激素和催乳素对刺激的反应
DOI：
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发表时间：
1987
影响因子：
5.4
通讯作者：
J. Beyer
中科院分区：
文献类型：
--
作者：
G. Plewe;U. Schneider;U. Krause;J. Beyer
阿片类药物刺激生长激素和催乳素对非肥胖人群的刺激反应。然而，肥胖患者表现出较低的生长激素和催乳素反应和升高的β-内啡肽水平。因此，我们在肥胖患者中进行了一项对照双盲研究，研究阿片拮抗剂纳洛酮对刺激生长激素和催乳素分泌的影响。所有患者均接受200µg TRH和0.5 g/kg b.w.精氨酸与2 mg纳洛酮或安慰剂静脉注射。纳洛酮组促乳素和生长激素水平明显高于TRH组（p < 0.05）。与安慰剂相比，纳洛酮还使ACTH、皮质醇和β-内啡肽显著增加。TSH、三碘甲状腺原氨酸、甲状腺素、胰岛素、胰高血糖素和血糖在试验的两天之间没有显示出显著差异。因此，纳洛酮对肥胖人群生长激素和催乳素分泌的影响可视为部分正常化。因此，我们的结论是，下丘脑的生长激素和催乳素分泌的调节障碍，在肥胖可能引起的阿片类药物水平升高。
Opiates stimulate the growth hormone and prolactin responses to stimuli in non-obese humans. Obese patients, however, show lowered growth hormone and prolactin responses and raised β-endorphin levels. We therefore investigated the effect of the opiate antagonist naloxone on the stimulated growth hormone and prolactin secretions in a controlled double-blind study in obese patients. All patients received 200µg TRH and 0.5 g/kg b.w. arginine together with 2 mg of naloxone or placebo i.v. in a randomized sequence. The TRH- and arginine-induced increases in prolactin and growth hormone were significantly greater after administration of naloxone (p < 0.05). Naloxone also produced a significant increase in ACTH, Cortisol and β-endorphin when compared with placebo. TSH, triiodothyronine, thyroxine, insulin, glucagon and blood glucose showed no significant differences between both days of the trial. The effect of naloxone on growth hormone and prolactin secretions in obese humans can thus be regarded as a partial normalization. We therefore conclude that the hypothalamic regulatory disturbance of growth hormone and prolactin secretions in the obese could be caused by raised opiate levels.
纳洛酮诱导的女性催乳素分泌：反对内源性阿片类药物直接催乳素刺激作用的证据。
DOI：
10.1210/jcem-60-1-191
发表时间：
1985
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Cetel,NS;Quigley,ME;Yen,SS
通讯作者：
Yen,SS
胰腺激素分泌的内源性阿片类药物调节：对狗的研究。
DOI：
10.1016/0026-0495(86)90096-x
发表时间：
1986
期刊：
Metabolism: clinical and experimental
影响因子：
--
作者：
Levin,ER;Yamada,T;Levin,S;Mills,S
通讯作者：
Mills,S
黄体生成素释放因子激动剂诱导催乳素和黄体生成素同时脉冲式释放。
DOI：
10.1210/jcem-52-5-934
发表时间：
1981
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Casper,RF;Yen,SS
通讯作者：
Yen,SS