Endogenous opioid effects on abdominal muscle activity during inspiratory loading.
Endogenous opioid effects on abdominal muscle activity during inspiratory loading.
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内源性阿片类药物对吸气负荷期间腹部肌肉活动的影响。
DOI：
10.1152/jappl.1990.69.3.1104
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Santiago,TV
中科院分区：
文献类型：
--
作者：
Scardella,AT;Petrozzino,JJ;Mandel,M;Edelman,NH;Santiago,TV
在先前对未麻醉山羊的研究中，我们证明在吸气阻力负荷(IRL)期间持续给予纳洛酮(NLX)显著增加潮气量(VT)，但不增加隔膜肌电(EMGdi)。呼气末胃压确实随着NLX的增加而增加，这意味着腹部肌肉活动的增加可能是NLX效应的原因。在目前的研究中，我们直接测试了内源性阿片类药物精制抑制腹肌对持续吸气流动阻力负荷的反应的假设。在7只未麻醉的山羊上，监测VT、动脉血气、EMGdi和外斜肌(EMGeo)、腹横肌(EMGta)和肋间外肌(EMGei)的肌电活动。IRL(50cmH_2O·l~(-1)·s)持续3h后，给予NLX(0.1 mg/kg)或生理盐水。结果显示，VT由负荷前的323+/-32(SE)ml降至负荷后5分钟的260+/-16ml(P<0.05)，至120分钟和180分钟分别降至229+/-18和217+/-15 ml(P<0.05)。EMGdi在5min时最大值由62+/-5增至83+/-4%(P<0.05)，但此后无明显变化。相反，在同一时间段，EMGeo从35+/-5增加到58+/-11%max，但从120min的67+/-11%max下降到180min的37+/-5max(P<0.05)。NLX给药后EMGeo显著增加(高于180min值91%)。相比之下，NLX后EMGdi的增加幅度最小(比180分钟的值高出15%)。
In a previous study in unanesthetized goats, we demonstrated that continuous naloxone (NLX) administration during inspiratory flow-resistive loading (IRL) significantly increased tidal volume (VT) but not diaphragm electromyogram (EMGdi). End-expiratory gastric pressure did increase with NLX, implying that increased abdominal muscle activity may have accounted for the NLX effect. In the current study we directly tested the hypothesis that endogenous opioid elaboration depresses the abdominal muscle response to a continuous inspiratory flow-resistive load. In seven unanesthetized goats, VT, arterial blood gases, EMGdi, and EMG activity of external oblique (EMGeo), transversus abdominis (EMGta), and external intercostal (EMGei) muscles were monitored. IRL (50 cmH2O.l-1.s) was continued for 3 h, after which NLX (0.1 mg/kg) or saline was given. Our results showed that VT decreased from 323 +/- 32 (SE) ml at baseline to 260 +/- 16 ml 5 min after the load was imposed (P less than 0.05) and further decreased to 229 +/- 18 and 217 +/- 15 ml by 120 and 180 min, respectively (180 vs. 5 min, P less than 0.05). EMGdi increased from 62 +/- 5 to 83 +/- 4% max at 5 min (P less than 0.05) but was unchanged thereafter. In contrast, for this same time period EMGeo increased from 35 +/- 5 to 58 +/- 11% max but decreased from 67 +/- 11% max at 120 min to 37 +/- 5% max at 180 min (P less than 0.05). NLX administration resulted in significant increases in EMGeo (91% above 180-min value). In contrast, EMGdi increased minimally after NLX (15% above 180-min value).(ABSTRACT TRUNCATED AT 250 WORDS)