Extraocular circadian phototransduction in humans
Extraocular circadian phototransduction in humans
复制标题
DOI：
10.1126/science.279.5349.396
复制
发表时间：
1998-01-16
期刊：
影响因子：
56.9
通讯作者：
Murphy, PJ
中科院分区：
文献类型：
--
作者：
Campbell, SS;Murphy, PJ
生理和行为节律由内源性生物钟控制。通过在向腘区（膝盖后面）发出光脉冲之前和之后的整个昼夜节律周期中测量体温和褪黑激素浓度来监测人类生物钟对眼外光照射的反应。在光脉冲的定时与相移的幅度和方向之间发现了系统关系，从而生成了相位响应曲线。这些发现挑战了哺乳动物无法进行视网膜外昼夜节律光转导的信念，并且对开发更有效的睡眠和昼夜节律紊乱治疗方法具有重要意义。
Physiological and behavioral rhythms are governed by an endogenous circadian clock. The response of the human circadian clock to extraocular light exposure was monitored by measurement of body temperature and melatonin concentrations throughout the circadian cycle before and after light pulses presented to the popliteal region (behind the knee). A systematic relation was found between the timing of the light pulse and the magnitude and direction of phase shifts, resulting in the generation of a phase response curve. These findings challenge the belief that mammals are incapable of extraretinal circadian phototransduction and have implications for the development of more effective treatments for sleep and circadian rhythm disorders.