SYSTEMIC LUPUS-ERYTHEMATOSUS IN AUSTRALIAN ABORIGINES - HIGH PREVALENCE, MORBIDITY AND MORTALITY
SYSTEMIC LUPUS-ERYTHEMATOSUS IN AUSTRALIAN ABORIGINES - HIGH PREVALENCE, MORBIDITY AND MORTALITY
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DOI：
10.1111/j.1445-5994.1993.tb04720.x
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发表时间：
1993-12-01
期刊：
影响因子：
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通讯作者：
CURRIE, BJ
中科院分区：
文献类型：
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作者：
ANSTEY, NM;BASTIAN, I;CURRIE, BJ
背景系统性红斑狼疮（SLE）的发病率存在种族差异。有研究表明，澳大利亚土著居民中SLE的患病率和严重程度较高，但由于人口基数小，分布广泛，这一点尚未得到很好的证明。目的：确认和记录澳大利亚土著居民中系统性红斑狼疮（SLE）患病率和严重程度增加的临床印象，并确定预后指标。方法：对1984年1月1日或此后诊断为SLE的北领地（NT）土著居民随访至1991年1月1日。流行病学，临床和血清学数据收集。结果：在1991年1月1日的患病率估计为1：1900，至少两倍的估计患病率在非土著澳大利亚人。发现肾脏疾病（62%，蛋白尿> 0.5 g/天）和Sm抗原自身抗体（29%）的高频率，导致高死亡率。五年生存率为60%，与67%的死亡原因infection.Conclusions：有一个高患病率的SLE在NT原住民。鉴于对轻度病例可能认识不足，实际流行率可能更高。虽然发病率和死亡率可能由于同样的原因而被高估，但两者都很高。改善生活条件和保健服务可改善预后。
Background. Racial differences occur in the incidence of systemic lupus erythematosus (SLE). It has been suggested that SLE occurs at a higher prevalence an with greater severity in Aboriginal Australians, but because of the small, widely distributed population base, this has not been well documented.Aims: To confirm and document the clinical impression of an increased prevalence and severity of systemic lupus erythematosus (SLE) in Aboriginal Australians, and to identify prognostic indicators.Methods: Top End Northern Territory (NT) Aborigines with SLE on 1 January 1984 or diagnosed thereafter were followed until 1 January 1991. Epidemiological, clinical and serological data were collected.Results: Prevalence on 1 January 1991 estimated at 1: 1900, at least twice the estimated prevalence in non-Aboriginal Australians. High frequencies of renal disease (62% with proteinuria > 0.5 g/day) and autoantibodies to the Sm antigen (29%) were identified, contributing to the high mortality. Five year survival rate was 60%, with 67% of deaths resulting from infection.Conclusions: There is a high prevalence of SLE in NT Aborigines. In view of probable under-recognition of mild cases the true prevalence is likely to be even higher. Although morbidity and mortality may have been overestimated for the same reason, both were found to be high. Improved living conditions and health care delivery may improve prognosis.