Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.
Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.
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DOI：
10.1002/adma.201501351
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发表时间：
2015-07-15
期刊：
影响因子：
--
通讯作者：
Alexander MR
中科院分区：
文献类型：
--
作者：
Celiz AD;Smith JG;Patel AK;Hook AL;Rajamohan D;George VT;Flatt L;Patel MJ;Epa VC;Singh T;Langer R;Anderson DG;Allen ND;Hay DC;Winkler DA;Barrett DA;Davies MC;Young LE;Denning C;Alexander MR
提供了一种可扩展且具有成本效益的合成聚合物基质，其支持使用限定的商业培养基的人多能干细胞（hPSC）的稳健扩增和随后的多谱系分化。该基质可应用于普通培养皿，并在长期储存后使用。hPSC的扩增和分化完全在聚合物表面上进行，使得hPSC衍生细胞的临床潜力得以实现。
A scalable and cost‐effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off‐the‐shelf after long‐term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC‐derived cells to be realized.
影响因子：
12.3
作者：
Hirst M;Delaney A;Rogers SA;Schnerch A;Persaud DR;O'Connor MD;Zeng T;Moksa M;Fichter K;Mah D;Go A;Morin RD;Baross A;Zhao Y;Khattra J;Prabhu AL;Pandoh P;McDonald H;Asano J;Dhalla N;Ma K;Lee S;Ally A;Chahal N;Menzies S;Siddiqui A;Holt R;Jones S;Gerhard DS;Thomson JA;Eaves CJ;Marra MA
通讯作者：
Marra MA