THE EFFECT OF NICARDIPINE ON VASOSPASM IN RABBIT BASILAR ARTERY AFTER SUBARACHNOID HEMORRHAGE
THE EFFECT OF NICARDIPINE ON VASOSPASM IN RABBIT BASILAR ARTERY AFTER SUBARACHNOID HEMORRHAGE
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DOI：
10.1227/00006123-199108000-00003
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发表时间：
1991-08-01
期刊：
影响因子：
4.8
通讯作者：
TORNER, JC
中科院分区：
文献类型：
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作者：
PASQUALIN, A;VOLLMER, DG;TORNER, JC
本研究观察二氢吡啶类钙拮抗剂尼卡地平对兔蛛网膜下腔出血(SAH)后血管痉挛的影响。实验分两部分进行：1)静脉注射尼卡地平(n=45)；2)脑池内注射尼卡地平(n=21)。枕大池注入自体动脉血5ml诱导SAH。静脉研究分为5组：1)SAH不治疗；2)SAH+生理盐水；3)SAH+小剂量尼卡地平(0.01 mg/kg/h)静脉滴注；4)SAH+大剂量尼卡地平(0.15 mg/kg/h)静脉滴注；5)对照组不用SAH。SAH后即刻开始静脉输液，持续48小时直至死亡。在脑池内研究中，有三组：1)SAH不治疗；2)SAH+尼卡地平(0.37 mg/h)脑池内注射；3)对照组不用SAH。SAH后70小时开始脑池内输液，持续2小时直至死亡。灌注固定后，取出基底动脉进行形态计量学分析。在静脉研究中，与对照组相比，SAH动物的血管显著狭窄，尽管在大剂量尼卡地平治疗后，血管口径比其他SAH组略大。与对照组相比，脑池内注射尼卡地平的动物显示管径没有明显减小：直径仅减少12%，管腔面积减少22%。在兔蛛网膜下腔出血模型中，尼卡地平在测试剂量下对血管痉挛的影响非常轻微。
This study was performed to examine the effect of the dihydropyridine calcium antagonist, nicardipine, on vasospasm after experimental subarachnoid hemorrhage (SAH) in the rabbit. The study was carried out in two parts: 1) effect of intravenous nicardipine (n = 45) and 2) effect of intracisternal nicardipine (n = 21). SAH was induced by injecting 5 ml of autologous arterial blood into the cisterna magna. In the intravenous study, there were five groups: 1) SAH without treatment; 2) SAH with vehicle (saline); 3) SAH and intravenous infusion of low-dose nicardipine (0.01 mg/kg/h); 4) SAH and intravenous infusion of high-dose nicardipine (0.15 mg/kg/h); and 5) controls without SAH. The intravenous infusions were started immediately after SAH and continued for 48 hours until death. In the intracisternal study, there were three groups: 1) SAH without treatment; 2) SAH with intracisternal administration of nicardipine (0.37 mg/h); and 3) controls without SAH. Intracisternal infusions were begun 70 hours after SAH and continued for 2 hours until death. After perfusion-fixation, the basilar artery was removed and processed for morphometric analysis. In the intravenous study, vessels from animals subjected to SAH were significantly narrowed when compared with controls, although after high-dose nicardipine vessel caliber was slightly larger than in the other SAH groups. Animals given intracisternal nicardipine showed a nonsignificant reduction of caliber as compared with controls: only 12% decrease in diameter and 22% decrease in luminal area. In the rabbit SAH model, nicardipine had a very modest effect on vasospasm at the doses tested.