Self-reported diabetes mellitus and risk of mortality from all causes, cardiovascular disease, and cancer in Takayama: a population-based prospective cohort study in Japan.
Self-reported diabetes mellitus and risk of mortality from all causes, cardiovascular disease, and cancer in Takayama: a population-based prospective cohort study in Japan.
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DOI：
10.2188/jea.je2008004
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发表时间：
2008
影响因子：
4.7
通讯作者：
Shimizu H
中科院分区：
文献类型：
--
作者：
Oba S;Nagata C;Nakamura K;Takatsuka N;Shimizu H
糖尿病已被报道为心血管疾病（CVD）的主要危险因素，并且在许多研究中观察到女性CVD的风险高于男性。此外，糖尿病与癌症风险增加的相关性也有报道。在日本普通人群中进行的精心设计的研究仍然很少。我们的队列包括13355名男性和15724名女性居住在高山，日本，在1992年。在基线时，受试者在问卷中报告糖尿病。使用国家生命统计局的数据记录了1999年之前队列中发生的任何死亡。在调整年龄、吸烟状况、体重指数（BMI）、体力活动、受教育年限、高血压史、总能量、蔬菜、脂肪和酒精摄入量后，采用考克斯比例风险模型分别评估男性和女性的死亡风险。糖尿病显著增加了所有原因[风险比（HR）：1.35，95%置信区间（CI）：1.11-1.64]和冠心病（CHD）的死亡风险在男性中，所有原因（HR：2.96，95% CI：1.59-5.50）和癌症（HR：1.88，95% CI：1.16-3.05）在女性中的差异显著（HR：1.74，95% CI：1.34-2.26）。糖尿病与女性冠心病死亡率无显著相关性。研究结果表明，糖尿病增加了男性心血管疾病和女性癌症的死亡风险。女性冠心病死亡风险没有增加，这可能表明日本人群中存在一种特殊的模式。
Diabetes mellitus has been reported to be a major risk factor for cardiovascular disease (CVD), and higher risk of CVD among women than that among men has been observed in many studies. Further, the association of diabetes with increasing risk of cancer has also been reported. Well-designed studies conducted among men and women in the general Japanese population remain scarce. Our cohort consisted of 13355 men and 15724 women residing in Takayama, Japan, in 1992. At the baseline, the subjects reported diabetes in a questionnaire. Any deaths occurring in the cohort until 1999 were noted by using data from the Office of the National Vital Statistics. The risk of mortality was separately assessed for men and women by using a Cox proportional hazard model after adjusting for age; smoking status; body mass index (BMI); physical activity; years of education; history of hypertension; and intake of total energy, vegetables, fat, and alcohol. Diabetes significantly increased the risk of mortality from all causes [hazard ratio (HR): 1.35, 95% confidence interval (CI): 1.11-1.64] and from coronary heart disease (CHD) (HR: 2.96, 95% CI: 1.59-5.50) among men, and that from all causes (HR: 1.74, 95% CI: 1.34-2.26) and cancer (HR: 1.88, 95% CI: 1.16-3.05) among women. Diabetes was not significantly associated with mortality from CHD among women. The findings suggest that diabetes increases the risk of mortality from CVD among men and that from cancer among women. The absence of increased risk of mortality from CHD among women may suggest a particular pattern in the Japanese population.