Elimination of zinc-65 from the brain under kainate-induced seizures
Elimination of zinc-65 from the brain under kainate-induced seizures
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DOI：
10.1023/b:biom.0000018378.55494.d2
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发表时间：
2004-04-01
期刊：
影响因子：
3.5
通讯作者：
Oku, N
中科院分区：
文献类型：
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作者：
Takeda, A;Hirate, M;Oku, N
根据癫痫小鼠脑内锌-65浓度受致痫诱导影响的研究结果，定量研究了红藻氨酸对癫痫小鼠脑内锌-65运动的影响。静脉注射(ZnCl2)-ZN-65后6d，腹腔注射红藻氨酸(10 mg/kg×6次，共2周)。在红藻氨酸治疗过程中观察到肌阵挛发作。注射锌-65 20天后，比较处理组和对照组小鼠脑内锌-65的分布。海人酸组小鼠脑内锌-65的分布总体上低于对照组。红藻氨酸可显著降低额叶皮质、海马CA1区、丘脑和下丘脑的锌-65含量。这些结果表明，红藻氨酸诱导的癫痫发作与大脑中锌浓度的降低有关。
On the basis of the previous evidence that Zn-65 concentrations in the brain of EL ( epilepsy) mice was affected by induction of seizures, Zn-65 movement in the brain was quantitatively evaluated in ddY mice treated with kainate. Six days after intravenous injection of (ZnCl2)-Zn-65, mice were intraperitoneally injected with kainate (10 mg/kg x 6 times in 2 weeks). Myoclonic jerks were observed during treatment with kainate. Twenty days after Zn-65 injection, Zn-65 distribution in the brain was compared between the kainite-treated and control mice. Zn-65 distribution in the brain of the kainate-treated mice was overall lower than in the control mice. Zn-65 concentration was significantly decreased in the frontal cortex, hippocampal CA1, thalamus and hypothalamus by treatment with kainate. These results demonstrate that kainate-induced seizures are linked to decreased zinc concentrations in the brain.