Conformation of equine pituitary somatotropin.
Conformation of equine pituitary somatotropin.
复制标题
马垂体生长激素的构象。
DOI：
10.1111/j.1399-3011.1987.tb02288.x
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Li,CH
中科院分区：
文献类型：
--
作者：
Bewley,TA;Li,CH
马垂体生长激素（生长激素）已通过零级和二级吸收光谱以及圆二色性进行了研究。在激素的蛋白水解消化过程中也会产生差异吸收光谱。天然蛋白质的摩尔消光系数在 278.1 nm 处为 16050 ± 330 M-1cm-1。马生长激素和从其他几种哺乳动物中分离的生长激素的构象比较表明这些分子之间存在密切的结构关系。随着所研究的物种数量不断增加，越来越明显的是，就构象而言，生长激素可细分为至少三大类。
Equine pituitary somatotropin (growth hormone) has been studied by zero‐order and second‐order absorption spectroscopy, and by circular dichroism. Difference absorption spectra have also been generated during proteolytic digestion of the hormone. The molar extinction coefficient of the native protein was found to be 16050 ± 330 M‐1cm‐1at 278.1 nm. Comparison of the conformations of equine somatotropin and somatotropins isolated from several other mammalian species indicates a close structural relationship between these molecules. With the increasing number of species which have been studied, it is becoming evident that with regard to conformation, the somatotropins can be subdivided into at least three major groups.