Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
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DOI：
10.1080/07420528.2020.1756841
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发表时间：
2020-05-10
影响因子：
2.8
通讯作者：
de Mello, Marco Tulio
中科院分区：
文献类型：
--
作者：
da Silva, Flavia Rodrigues;Guerreiro, Renato de Carvalho;de Mello, Marco Tulio
轮流和永久的夜班工作安排通常会导致急性（有时是慢性）睡眠剥夺，以及昼夜节律时间结构的急性（有时是慢性）破坏。免疫系统的过程和功能是按照昼夜节律组织的，它们也受到睡眠状态的强烈影响。睡眠是生物的一种重要行为状态，是免疫功能和反应性的调节器。由于先天和获得性免疫反应可能受到损害，倒班工人患病毒感染的风险增加。睡眠不足和睡眠不足是轮班工作的常见后果，与免疫系统完整性的改变有关。我们讨论了在轮班工人（包括护士、医生和急救人员）以及其他高度暴露于传染病、睡眠不平衡和昼夜节律紊乱的人群中常见的情况下，COVID-19感染可能存在的超额风险。
Rotating and permanent night shiftwork schedules typically result in acute and sometimes chronic sleep deprivation plus acute and sometimes chronic disruption of the circadian time structure. Immune system processes and functionalities are organized as circadian rhythms, and they are also strongly influenced by sleep status. Sleep is a vital behavioral state of living beings and a modulator of immune function and responsiveness. Shiftworkers show increased risk for developing viral infections due to possible compromise of both innate and acquired immunity responses. Short sleep and sleep loss, common consequences of shiftwork, are associated with altered integrity of the immune system. We discuss the possible excess risk for COVID-19 infection in the context of the common conditions among shiftworkers, including nurses, doctors, and first responders, among others of high exposure to the contagion, of sleep imbalance and circadian disruption.