Nanomechanical properties of poly(lactic-co-glycolic) acid film during degradation
Nanomechanical properties of poly(lactic-co-glycolic) acid film during degradation
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DOI：
10.1016/j.actbio.2014.08.004
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发表时间：
2014-11-01
影响因子：
9.7
通讯作者：
McHugh, Peter
中科院分区：
文献类型：
--
作者：
Shirazi, Reyhaneh Neghabat;Aldabbagh, Fawaz;McHugh, Peter
尽管聚（乳酸-羟基乙酸）（PLGA）涂层在医疗器械中具有潜在的应用，但对该材料在降解过程中的机械性能了解甚少。本工作研究了PLGA膜的纳米力学性能和降解性能。在37 ℃的缓冲溶液中研究了溶剂浇铸PLGA膜的水解。在降解过程中跟踪了20天的质量损失、吸水率、分子量、结晶度和膜的表面形态。使用纳米压痕技术进行表征的表面硬度和杨氏模量为不同的压痕载荷。最初的非晶薄膜被发现在降解过程中保持非晶。在降解的最初几天，膜的分子量迅速下降。水扩散到膜中导致在最初几天内表面硬度降低，随后由于表面粗糙度而增加。薄膜机械性能下降与分子量下降之间存在显着延迟。机械性能的突然下降表明发生了显著的本体降解。(C)2014 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Despite the potential applications of poly(lactic-co-glycolic) acid (PLGA) coatings in medical devices, the mechanical properties of this material during degradation are poorly understood. In the present work, the nanomechanical properties and degradation of PLGA film were investigated. Hydrolysis of solvent-cast PLGA film was studied in buffer solution at 37 C. The mass loss, water uptake, molecular weight, crystallinity and surface morphology of the film were tracked during degradation over 20 days. Characterization of the surface hardness and Young's modulus was performed using the nanoindentation technique for different indentation loads. The initially amorphous films were found to remain amorphous during degradation. The molecular weight of the film decreased quickly during the initial days of degradation. Diffusion of water into the film resulted in a reduction in surface hardness during the first few days, followed by an increase that was due to the surface roughness. There was a significant delay between the decrease in the mechanical properties of the film and the decrease in the molecular weight. A sudden decline in mechanical properties indicated that significant bulk degradation had occurred. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.