Effects of secretin and gastric inhibitory polypeptide on human pancreatic growth hormone-releasing factor(1-40)-stimulated growth hormone levels in the rat.
Effects of secretin and gastric inhibitory polypeptide on human pancreatic growth hormone-releasing factor(1-40)-stimulated growth hormone levels in the rat.
复制标题
促胰液素和抑胃多肽对大鼠体内人胰腺生长激素释放因子(1-40)刺激的生长激素水平的影响。
DOI：
10.1016/0006-291x(83)91488-2
复制
发表时间：
1983
影响因子：
3.1
通讯作者：
Coy,DH
中科院分区：
文献类型：
--
作者：
Murphy,WA;Lance,VA;Sueiras-Diaz,J;Coy,DH
含有40个氨基酸的合成人胰腺生长激素释放因子（[hpGRF (1-40)]-OH）显著刺激戊巴比妥钠和氨基甲酸乙酯麻醉大鼠血浆生长激素（GH）水平。合成分泌素、胃抑制多肽（GIP）和胰高血糖素可显著降低血浆GH水平，而合成血管活性肠肽（VIP）则无显著作用。分泌素和GIP也改变了体内血浆GH对[hpGRF (1-40)]-OH的反应。这种作用是垂体水平相互作用的结果，还是由于分泌素和GIP的垂体外作用，有待进一步研究。
Synthetic human pancreatic growth hormone-releasing factor containing 40 amino acids ([hpGRF (1–40)]-OH) significantly stimulated plasma growth hormone (GH) levels in both sodium pentobarbital and urethane anesthetized rats. Synthetic secretin, gastric inhibitory polypeptide (GIP), and glucagon significantly decreased plasma GH levels while synthetic vasoactive intestinal peptide (VIP) had no effect. Secretin and GIP also altered the in vivo plasma GH response to [hpGRF (1–40)]-OH. Whether this effect is the result of an interaction at the pituitary level or is due to an extra-pituitary effect of secretin and GIP awaits further study.