Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders.
Temperament and character traits in patients with bipolar disorder and associations with comorbid alcoholism or anxiety disorders.
复制标题
双相情感障碍患者的气质和性格特征以及与共病酒精中毒或焦虑症的关系。
DOI：
10.1016/j.jpsychires.2007.06.004
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发表时间：
2008
影响因子：
4.8
通讯作者：
Soares,JairC
中科院分区：
文献类型：
--
作者：
Nery,FabianoG;Hatch,JohnP;Glahn,DavidC;Nicoletti,MarkA;Monkul,ESerap;Najt,Pablo;Fonseca,Manoela;Bowden,CharlesL;Cloninger,CRobert;Soares,JairC
气质和性格特征可能决定双相情感障碍的临床表现和结局的差异。我们使用气质和性格问卷(TCI)比较了双相患者和健康人的人格特征，并试图验证酗酒或焦虑症的共病是否与特定的人格特征有关。73名DSM-IV双相情感障碍患者与63名使用TCI的健康人进行了比较。在第二步中，双相样本根据精神疾病共病的存在情况进行分组(酒精中毒，n=10；焦虑症；n=23；酒精中毒+焦虑症，n=21；无共病，n=19)。双相情感障碍患者在寻求新颖性、避免伤害和自我超越方面得分高于健康人，而在自我指导性和合作性方面得分低于健康人。在持续性方面，仅合并酒精中毒的双相情感障碍患者得分低于没有任何共病的双相情感障碍患者。与没有任何共病的双相情感障碍患者相比，只有焦虑障碍的双相情感障碍患者在伤害回避和自我定向方面的得分在统计学上更高，更低。这项研究的局限性包括横断面设计和样本量小，特别是在亚组分析方面。然而，我们的结果表明，双相患者表现出与健康人不同的人格结构，双相障碍中精神疾病的存在与特定的人格特征有关。这些发现表明，人格至少在一定程度上调节了双相情感障碍的共病现象。
Temperament and character traits may determine differences in clinical presentations and outcome of bipolar disorder. We compared personality traits in bipolar patients and healthy individuals using the Temperament and Character Inventory (TCI) and sought to verify whether comorbidity with alcoholism or anxiety disorders is associated with specific personality traits. Seventy-three DSM-IV bipolar patients were compared to 63 healthy individuals using the TCI. In a second step, the bipolar sample was subgrouped according to the presence of psychiatric comorbidity (alcoholism, n=10; anxiety disorders; n=23; alcoholism plus anxiety disorders, n=21; no comorbidity, n=19). Bipolar patients scored statistically higher than the healthy individuals on novelty seeking, harm avoidance and self-transcendence and lower on self-directedness and cooperativeness. Bipolar patients with only comorbid alcoholism scored statistically lower than bipolar patients without any comorbidity on persistence. Bipolar patients with only comorbid anxiety disorders scored statistically higher on harm avoidance and lower on self-directedness than bipolar patients without any comorbidity. Limitations of this study include the cross-sectional design and the small sample size, specifically in the analysis of the subgroups. However, our results suggest that bipolar patients exhibit a different personality structure than healthy individuals and that presence of psychiatric comorbidity in bipolar disorder is associated with specific personality traits. These findings suggest that personality, at least to some extent, mediates the comorbidity phenomena in bipolar disorder.