Volume history effects and airway responsiveness in middle-aged and older men. The Normative Aging Study.
Volume history effects and airway responsiveness in middle-aged and older men. The Normative Aging Study.
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中年和老年男性的容量历史影响和气道反应性。
DOI：
10.1164/ajrccm.155.3.9117022
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
IngramJr,RH
中科院分区：
文献类型：
--
作者：
Sparrow,D;O'Connor,GT;Weiss,ST;DeMolles,D;IngramJr,RH
对于哮喘患者，深吸气(DI)至总肺活量可能会导致支气管收缩。这种效应的强度已被证明与炎性气流阻塞的严重程度和乙酰甲胆碱气道反应性的水平呈正相关。然而，普通人群中肺容量病史效应的相关性尚不清楚。我们分析了参加标准老龄化研究的中老年男性的最大和部分呼气流量-容量数据、支气管扩张剂治疗前和治疗后的肺活量测定数据以及乙酰甲胆碱激发数据。最大呼气流速与部分呼气流速的比值(Vm/Vp)与乙酰甲胆碱的气道反应性显著相关，即使在调整了年龄和基线FEV1后也是如此。这种相关性的方向表明，具有更高的Vm/VP比率(即，DI的扩张器效应更大)的男性倾向于具有更强的乙酰甲胆碱气道反应性。Vm/Vp比值较高的受试者对支气管扩张剂的反应也往往更大。这些结果表明，在普通人群中，气道反应性在一定程度上与气道平滑肌张力有关。这些相关性表明，这一相对简单的操作可能会在未来的流行病学研究中发挥作用。
In persons with asthma, a deep inhalation (DI) to total lung capacity may lead to bronchoconstriction. The intensity of this effect has been shown to correlate positively with the severity of inflammatory airflow obstruction and the level of methacholine airway responsiveness. The correlates of lung volume history effects in the general population, however, are unknown. We analyzed combined maximal and partial expiratory flow-volume data, pre- and postbronchodilator spirometry data, and methacholine challenge data from 89 middle-aged and older men participating in the Normative Aging Study. The ratio of maximal to partial expiratory flow rates (VM/VP) was significantly correlated with methacholine airway responsiveness, even after adjustment for age and baseline FEV1. The direction of this correlation indicated that men with higher VM/VP ratios (i.e., greater dilator effect of a DI) tended to have greater methacholine airway responsiveness. Subjects with a higher VM/VP ratio also tended to have a greater response to a bronchodilator. These results suggest that, in the general population, airway responsiveness relates in part to airway smooth muscle tone. The correlations suggest that this relatively simple maneuver might play a role in future epidemiologic studies.