Reaction patterns in selected lymphatic tissues associated with sudden infant death (SID)
Reaction patterns in selected lymphatic tissues associated with sudden infant death (SID)
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DOI：
10.1007/s004140050032
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发表时间：
1997-04-01
影响因子：
2.1
通讯作者：
Brinkmann, B
中科院分区：
文献类型：
--
作者：
Bajanowski, T;Ortmann, C;Brinkmann, B
用组织学和免疫组织化学方法(CD20、21、45RO)对50例猝死婴儿的颈、气管旁和肺门部淋巴结、胸腺和脾进行了观察。根据尸检结果包括广泛的组织学结果，将病例分为3组：A-无病变(N=12)，B-轻度至中度炎症(N=23)，C-重度炎症(N=15)。与先前的结果一致，从A组到C组，“病理性”淋巴结改变的频率增加，如皮质旁淋巴组织增生和牙髓斑点状增生。B细胞抗原相应地起反应。从A组到C组，也越来越多地观察到胸腺明显的淋巴枯竭，这是T细胞系统长期刺激的迹象。总而言之，在所有病例中，所获得的结果都不表明T细胞或B细胞系统存在缺陷。A组的结果似乎表明，淋巴组织反应模式的改变可能是一种比局部组织学更敏感的早期炎症检测方法。
In 50 cases of sudden infant death cervical, paratracheal and lung hilar lymph nodes, the thymus and the spleen were investigated by histology and immunohistochemistry (CD 20, 21, 45RO). The cases were divided into 3 groups based on autopsy findings including extensive histology: A - without pathological changes (N = 12), B - with minimal to intermediate inflammation (N = 23) and C - with severe inflammation (N = 15). In accordance with previous results the frequency of ''pathological'' lymph node changes, such as paracortical lymphoid hyperplasia and variegated hyperplasia of the pulp increased from group A to group C. The B-cell antigens reacted accordingly. A pronounced lymphodepletation of the thymus as a sign of a long lasting stimulation of the T-cell system was also observed increasingly from group A to C, In summary, in none of the cases results obtained were indicative of a defect of the T- or B-cell system. The results in group A seem to indicate that changes in the reaction pattern of the lymphoid tissues could be a more sensitive method of detection of early stages of inflammation than local histology.