Mucosal IL-7-mediated immune responses in chronic colitis-IL-7 transgenic mouse model
Mucosal IL-7-mediated immune responses in chronic colitis-IL-7 transgenic mouse model
复制标题
慢性结肠炎-IL-7转基因小鼠模型中粘膜IL-7介导的免疫反应
DOI：
10.1007/bf02790408
复制
发表时间：
1999
影响因子：
4.4
通讯作者：
T. Hibi
中科院分区：
文献类型：
--
作者：
Mamoru Watanahe;Y. Ueno;M. Yamazaki;T. Hibi
我们已经证明，肠上皮细胞产生白细胞介素-7（IL-7）和IL-7作为粘膜淋巴细胞增殖的调节因子。为了阐明局部产生的IL-7调节粘膜淋巴细胞的机制以及粘膜IL-7在结肠炎症中的作用，我们研究了IL-7转基因（IL-7 Tg）小鼠，并证明IL-7 Tg小鼠发生急性和慢性结肠炎，其组织病理学与人类溃疡性结肠炎相似。与我们最近的发现一致，IL-7刺激人溃疡性结肠炎炎症粘膜中失活粘膜淋巴细胞的增殖，但消除活化的淋巴细胞。这些发现表明，结肠粘膜的慢性炎症是由上皮细胞来源的IL-7系统的失调介导的。
We have demonstrated that intestinal epithelial cells produce interleukin-7 (IL-7) and IL-7 serves as a regulatory factor for proliferation of mucosal lymphocytes. To clarify the mechanism by which locally produced IL-7 regulates mucosal lymphocytes and the role of mucosal IL-7 in colonic inflammation, we investigated IL-7 transgenic (IL-7 Tg) mice and demonstrated that IL-7 Tg mice developed acute and chronic colitis with histopathological similarity to ulcerative colitis in humans. In concert with our recent findings that IL-7 stimulates the proliferation of inactivated mucosal lymphocytes but eliminates activated lymphocytes in the inflamed mucosa of human ulcerative colitis. These findings suggest that chronic inflammation in the colonie mucosa is mediated by dysregulation of epithelial cell-derived IL-7 system.