Mechanism for maintaining homeostasis in the immune system of the intestine.
Mechanism for maintaining homeostasis in the immune system of the intestine.
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DOI：
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发表时间：
2009-11
影响因子：
2
通讯作者：
Yoshie Taniguchi;Noriko Yoshioka;K. Nakata;T. Nishizawa;H. Inagawa;C. Kohchi;G. Soma
中科院分区：
文献类型：
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作者：
Yoshie Taniguchi;Noriko Yoshioka;K. Nakata;T. Nishizawa;H. Inagawa;C. Kohchi;G. Soma
每个有机体都有一种维持动态平衡的机制。我们的重点是免疫系统，作为一个系统，帮助维持体内的动态平衡，特别是肠道作为人体最大的免疫器官。我们还重点研究了肠道对外来物质的反应机制，特别是Toll样受体(Toll-like Receptor，TLR)。肠道中髓系分化初级反应基因88(MyD88)信号转导通路的激活作为对TLR的应答，被认为有助于通过肠道的稳态来维持机体的稳态。此外，有重要的发现表明，TLR4的信号转导对于肠道的维持和调节是必不可少的。这些结果有力地表明，TLR4可能维持肠道内的动态平衡，而TLR4在暴露于脂多糖(LPS)后发出的信号可能在调节动态平衡中起作用。预计使用TLR4预防和治疗各种疾病将继续发展。由于内毒素是一种增强TLR4活性的物质，它本身也将作为一种有价值的物质而引起人们的注意。
Every organism possesses a mechanism for maintaining homeostasis. We have focused on the immune system as a system that helps maintain homeostasis of the body, and particularly on the intestine as the largest organ of immunity in the body. We have also focused our research on the mechanism that responds to foreign substances in the intestine, especially the toll-like receptors (TLR). The activation of myeloid differentiation primary response gene 88 (MyD88) signal transduction as a response to TLR in the intestine is believed to contribute to the maintenance of homeostasis of the body through the homeostasis of the intestine. Furthermore, significant findings were reported in which signal transduction from TLR4 was essential for the maintenance and regulation of the intestine. These results strongly suggest the possibility that homeostasis in the intestine is maintained by TLR4, and signaling by TLR4 after exposure to lipopolysaccharide (LPS) probably has a role in regulating homeostasis. It is expected that the prevention and treatment of various diseases using TLR4 will continue to develop. As LPS is a substance that enhances the activity of TLR4, it will also attract attention as a valuable substance in its own right.