Change in the State of Neurons in the Medulla Oblongata of Fish Perccottus glehni during Wintering (Ultrastructural and Biochemical Studies)
Change in the State of Neurons in the Medulla Oblongata of Fish Perccottus glehni during Wintering (Ultrastructural and Biochemical Studies)
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DOI：
10.1134/s1990519x20030037
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发表时间：
2020-05-01
影响因子：
--
通讯作者：
Khutsian, S. S.
中科院分区：
文献类型：
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作者：
Gordon, R. Ya.;Santalova, I. M.;Khutsian, S. S.
本研究的目的是进行比较分析的神经元的延髓（MO）在越冬期间，并确定在适应不利条件（缺氧，低温，饥饿）的合成和降解系统的组成部分的作用进行分析。位于MO的Mautner神经元（MN）具有广泛的代谢和功能能力。它们被证明能够积累糖原，具有自己的糖原生成、糖原分解和糖原沉积系统，这是越冬期间的替代能量来源。MO神经元位于MN的躯体部分附近的研究表明，这些细胞中的一些，像MN，能够诱导一个类似的额外的能源-糖原-所示的外观糖原领域在其细胞质中越冬。在这些细胞中，就像在MNs中一样，在此期间，超微结构的成分保持在活性状态。粗面内质网和多聚核糖体在其中保持完整的结构。同时，高尔基体显著重组，分解代谢系统被激活。在与MN相邻的其他细胞中，其中没有糖原积累，观察到结构降解。因此，所研究的MO神经元的超微结构的特征表明，在越冬期间，糖原在其功能中的重要作用。可以认为，在延髓，MNs和其他一些神经元保留其活动，形成特定的中心，参与鱼类适应不利的越冬条件。
The aim of this study was to conduct a comparative analysis of the ultrastructure of neurons of the medulla oblongata (MO) in fish during wintering and to identify the role of components of the synthesis and degradation systems in adapting to unfavorable conditions (hypoxia, hypothermia, starvation). Mautner neurons (MNs) localized in the MO have a wide set of metabolic and functional capabilities. They were shown to be able to accumulate glycogen, having their own system of glycogenesis, glycogenolysis, and deposition of glycogen, which is an alternative source of energy during wintering. The study of MO neurons located near the somatic part of the MN showed that some of these cells, like the MNs, are able to induce a similar additional energy source-glycogen-as indicated by the appearance of glycogen fields in their cytoplasm during wintering. In such cells, as in MNs, during this period, the components of the ultrastructure remain in an active state. The rough endoplasmic reticulum and polyribosomes retain an intact structure in them. At the same time, the Golgi apparatus is reorganized significantly and the catabolic system is activated. In other cells adjacent to MNs, in which there is no accumulation of glycogen, structural degradation is observed. Thus, the features of the ultrastructure of the studied MO neurons indicate the important role of glycogen in their functioning during the wintering period. It can be suggested that, in the medulla oblongata, MNs and some other neurons retain their activity, forming specific centers that are involved in the adaptation of fish to adverse wintering conditions.