Intergenic IncRNAs and the evolution of gene expression
Intergenic IncRNAs and the evolution of gene expression
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DOI：
10.1016/j.gde.2014.03.009
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发表时间：
2014-08-01
影响因子：
4
通讯作者：
Ponting, Chris P.
中科院分区：
文献类型：
--
作者：
Marques, Ana C.;Ponting, Chris P.
真核生物基因组编码数量惊人的非编码转录本。大约三分之二的人类转录基因座不编码蛋白质，许多是基因间的，产生长（>200个核苷酸）的非编码RNA（IncRNA）。使用比较基因组学和转录组学方法进行的广泛分析已经确定，IncRNA序列和转录在进化过程中倾向于迅速翻转。我们对IncRNA的生物学作用的理解仅基于少数具有良好特征的功能的转录本，即IncRNA在调节基因表达中具有多种作用。这些建议的作用，连同其快速的进化速度表明，IncRNA可能有助于不同的物种之间观察到的表达模式和潜在的新性状的起源。
Eukaryote genomes encode a surprisingly large number of noncoding transcripts. Around two-thirds of human transcribed loci do not encode protein, and many are intergenic and produce long (>200 nucleotides) noncoding RNAs (IncRNAs). Extensive analyses using comparative genomics and transcriptomics approaches have established that IncRNA sequence and transcription tend to turn over rapidly during evolution. Our appreciation of the biological roles of IncRNAs, based only on a handful of transcripts with well-characterized functions, is that IncRNAs have diverse roles in regulating gene expression. These proposed roles together with their rapid rates of evolution suggest that IncRNAs could contribute to the divergent expression patterns observed among species and potentially to the origin of new traits.