HLA-G and NK receptor are expressed in psoriatic skin - A possible pathway for regulating infiltrating T cells?
HLA-G and NK receptor are expressed in psoriatic skin - A possible pathway for regulating infiltrating T cells?
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DOI：
10.1016/s0002-9440(10)61675-6
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发表时间：
2001-07-01
影响因子：
6
通讯作者：
Carosella, ED
中科院分区：
文献类型：
--
作者：
Aractingi, S;Briand, N;Carosella, ED
最近的数据表明，在银屑病中，T浸润细胞可能通过自然杀伤受体接受调节途径。HLA-G与不同的自然杀伤受体结合，能够抑制T细胞功能，因为这种分子是由干扰素-γ诱导的，干扰素-γ是银屑病中的一种主要细胞因子，我们想知道HLA-G及其受体是否可能在这种疾病中表达。HLA-G1和HLA-G5的特异性RNA在皮损皮肤标本中一致发现，可溶性HLA-G5转录物仅在银屑病中发现。在所有银屑病切片中均发现HLA-G蛋白，但在正常皮肤对照中从未发现。双标显示HLA-G阳性细胞为CD 68（+）、CD 11 c（+）巨噬细胞。银屑病皮肤中也存在NKR ILT 2，T CD 4（+）浸润细胞确实表达ILT 2。银屑病皮肤中HLA-G和ILT 2表达的证明表明，该途径可能作为抑制性反馈，旨在下调这种疾病中T细胞浸润的有害作用。
Recent data have suggested that in psoriasis, the T-infiltrating cells could be submitted to regulatory pathways, possibly through natural killer receptors. HLA-G binds to different natural killer receptors and is able to inhibit T-cell functions, because this molecule is Induced by interferon-gamma, a major cytokine in psoriasis, we asked whether HLA-G and its receptor might be expressed in this disease. Specific RNAs for HLA-G1 and HLA-G5 were consistently found in lesional skin specimens, soluble HLA-G5 transcripts being found only in psoriasis. HLA-G protein was found in all psoriatic sections, but never In normal skin controls. Double labeling demonstrated that HLA-G-positive cells were CD68(+), CD11c(+) macrophages. The NKR ILT2 was also present In psoriatic skin, the T CD4(+)-infiltrating cells expressing indeed ILT2, The demonstration of HLA-G and ILT2 expression in psoriatic skin suggests that this pathway may act as an inhibitory feed back aimed to down-regulate the deleterious effects of T-cell infiltrate in this disease.