Cancer Survivors' Uptake and Adherence in Diet and Exercise Intervention Trials: An Integrative Data Analysis
Cancer Survivors' Uptake and Adherence in Diet and Exercise Intervention Trials: An Integrative Data Analysis
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DOI：
10.1002/cncr.28978
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发表时间：
2015-01-01
期刊：
影响因子：
6.2
通讯作者：
Demark-Wahnefried, Wendy
中科院分区：
文献类型：
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作者：
Adams, Rebecca N.;Mosher, Catherine E.;Demark-Wahnefried, Wendy
背景：饮食和运动干预对癌症幸存者的健康益处是有据可查的。然而，对于幸存者参与饮食和运动干预试验的意愿、研究登记、干预坚持和研究完成的人口统计学和医学预测因素知之甚少。为了帮助解释试验结果的概括性并改进未来试验的设计，本研究检验了这些过程测量的预测因素。方法对3个针对癌症幸存者的最大家庭饮食和运动干预试验(n=23,841)的数据进行综合数据分析。人口统计学和医学因素(即性别、种族、年龄、确诊时间和癌症类型)被检验为参与意愿、研究登记、干预坚持和研究完成率的预测因子。用99%的可信区间来确定统计学意义。结果在整个试验中，11.1%的联系幸存者愿意参与，5.7%的人符合条件并进入试验。在参与者中，53.4%的人表示坚持干预措施的75%，91.1%的人完成了研究。种族(高加索人与其他人)、年龄、确诊以来的时间和癌症类型预测幸存者参与的意愿(P<；.01)。所有被检查的预测因素都与研究入学的可能性有关(P<；.01)。在研究参与者中未发现显著的干预依从性或研究完成的预测因素(P。01)。结论癌症幸存者的人口学和医学特征预测了他们对饮食和运动干预试验的兴趣和参与。这些发现对结果的概括性有影响，并有助于指导未来试验中使用的程序，以增强患者的代表性。癌症2015；121：77-83。癌症幸存者的人口统计和医学特征决定了他们对饮食和运动干预试验的兴趣和参与程度。本文报告的结果有助于指导试验程序，以增强患者的多样性和代表性，并有助于解释概括性。
BACKGROUNDThe health benefits of diet and exercise interventions for cancer survivors are well documented. However, little is known regarding demographic and medical predictors of survivors' willingness to participate in diet and exercise intervention trials, study enrollment, intervention adherence, and study completion. To assist in interpreting the generalizability of trial findings and to improve the design of future trials, this study examined predictors of these process measures.METHODSAn integrative data analysis was performed on data from 3 of the largest home-based diet and exercise intervention trials for cancer survivors (n = 23,841). Demographic and medical factors (ie, sex, race, age, time since diagnosis, and cancer type) were examined as predictors of willingness to participate, study enrollment, intervention adherence, and study completion in the pooled sample. A 99% confidence interval was used to determine statistical significance.RESULTSAcross trials, 11.1% of contacted survivors were willing to participate, and 5.7% were eligible and enrolled. Among enrollees, 53.4% demonstrated 75% adherence to the intervention, and 91.1% completed the study. Race (Caucasian vs others), age, time since diagnosis, and cancer type predicted survivors' willingness to participate (P < .01). All examined predictors were associated with the likelihood of study enrollment (P < .01). No significant predictors of intervention adherence or study completion were found among study enrollees (P .01).CONCLUSIONSCancer survivors' demographic and medical characteristics predicted their interest and participation in diet and exercise intervention trials. These findings have implications for the generalizability of results and can help to guide procedures used in future trials to enhance patient representation. Cancer 2015;121:77-83. (c) 2014 American Cancer Society.Cancer survivors' demographic and medical characteristics predict their interest and participation in diet and exercise intervention trials. The findings reported here can help to guide trial procedures to enhance patient diversity and representation and assist with the interpretation of generalizability.