Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): MR-imaging is useful at initial diagnosis
Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): MR-imaging is useful at initial diagnosis
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DOI：
10.1023/a:1006427407281
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发表时间：
2000-07-01
影响因子：
3.9
通讯作者：
ten Velde, GPM
中科院分区：
文献类型：
--
作者：
Hochstenbag, MMH;Twijnstra, A;ten Velde, GPM
目的。在这项研究中，我们评估了磁共振成像在小细胞肺癌(SCLC)患者初诊时发现无症状性脑转移(BM)的有效性，并对这些患者的随访进行了研究。对125例小细胞肺癌患者进行了MRI检查。在112例神经学检查正常的患者中，17例(15%)脑部磁共振成像显示为骨髓瘤。因此，这17名患者中有6名升级为广泛性疾病(ED)。在这17名患者中，有两名患者在化疗期间死于进展性疾病，3名患者在脑部磁共振成像上出现了进展性疾病的神经症状。化疗结束后，12例患者复查头颅MRI，1例完全缓解，4例部分缓解，7例进展性骨髓瘤。这项研究表明，在表现时，小细胞肺癌患者中有出乎意料的高比例在磁共振成像上有无症状的骨髓。我们建议在小细胞肺癌患者的分期、预后和治疗中也应包括脑部的磁共振成像。
Purpose. In this study we evaluated the usefulness of MR-imaging in the detection of asymptomatic brain metastases (BM) at the initial diagnosis in patients with small cell lung cancer (SCLC) and studied the follow-up of these patients.Patients and methods. One-hundred and twenty-five patients with SCLC were investigated with MR-imaging.Results. In 112 patients with normal neurological findings, MR-imaging of the brain demonstrated BM in 17 patients (15%). Six of these 17 patients were therefore upgraded to extensive disease (ED). Two of these 17 patients died during chemotherapy because of progressive disease and 3 patients became neurologic symptomatic with progressive disease on MR-imaging of the brain. After completion of chemotherapy a repeated MR-imaging of the brain in the remaining 12 patients showed 1 complete remission, 4 partial remission and 7 progressive disease of the BM.Conclusion. This study showed that at presentation an unexpectedly high percentage of SCLC patients had asymptomatic BM on MR-imaging. We propose that MR-imaging of the brain should be included in the staging of SCLC patients as well for staging, prognosis and therapy.