Evolution in the frequency of nonsyndromic craniosynostosis Clinical article
Evolution in the frequency of nonsyndromic craniosynostosis Clinical article
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DOI：
10.3171/2009.3.peds08355
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发表时间：
2009-07-01
影响因子：
1.9
通讯作者：
Renier, Dominique
中科院分区：
文献类型：
--
作者：
Di Rocco, Federico;Arnaud, Eric;Renier, Dominique
Object.颅缝早闭不同亚型的患病率差异很大。本研究的目的是分析不同亚型的颅缝早闭的患病率在一个主要的颅面中心和他们的变化在20年的时间。回顾性分析了1988年至2007年间因真性颅缝早闭而住院的2808例儿童的病历。根据颅缝早闭的亚型（矢状、斜头、短头、额位、尖头、综合征病例或无法分类）对患者进行分类。根据颅缝早闭亚型，患者总数如下：舟状头畸形1224例，斜头畸形315例，三角头畸形598例，短头畸形105例，尖头畸形69例，综合征病例396例，以及无法分类的病例101例。这些颅缝早闭症的患病率随着时间的推移而变化。每年住院的儿童人数随着时间的推移从106例增加到181例，但这种增加因颅缝早闭的亚型而异。舟状头畸形、斜头畸形、短头畸形和综合征病例的增加相似（平均增加170%），而三角头畸形的增加幅度很大（增加420%）。颅缝早闭患病率的变化可能是由几个因素引起的。该中心患者招募的增加和颅缝早闭诊断的改善可能解释了总体增加。然而，应检查其他机制来解释三角头畸形病例数量的大幅增加（环境或药理学）。(DOI：10.3171/2009.3.PEDS08355）
Object. The prevalence of the different subtypes of craniosynostosis varies greatly. The aim of this study was to analyze the prevalences of the different subtypes of craniosynostosis at a single major craniofacial center and their changes during a 20-year period.Methods. The medical charts of 2808 children hospitalized between 1988 and 2007 for a true craniosynostosis were retrospectively reviewed. Patients were divided according to their subtype of craniosynostosis (sagittal, plagiocephaly, brachycephaly, metopic, oxycephaly, syndromic cases, or unclassifiable).Results. The total number of patients according to their craniosynostosis subtype were as follows: 1224 cases of scaphocephaly, 315 cases of plagiocephaly, 598 cases of trigonocephaly, 105 cases of brachycephaly, 69 cases of oxycephaly, 396 syndromic cases, and 101 unclassifiable cases. The prevalences of these craniosynostoses evolved differently over time. The number of children hospitalized each year increased over time from 106 to 181 cases, but this increase varied according to the subtype of craniosynostosis. Cases of scaphocephaly, plagiocephaly, brachycephaly, and syndromic cases increased similarly (170% increase on average), whereas trigonocephalies dramatically increased (420% increase).Conclusions. The evolution observed in the prevalence of craniosynostosis might result from several factors. An increased recruitment of patients at the center and an improvement in the diagnosis of craniosynostosis might explain the overall increase. However, other mechanisms should be examined to explain the great increase in the number of cases of trigonocephaly (environmental or pharmacological). (DOI: 10.3171/2009.3.PEDS08355)