Acute hydrocortisone administration does not affect subjective responses to d-amphetamine in humans.
Acute hydrocortisone administration does not affect subjective responses to d-amphetamine in humans.
复制标题
急性氢化可的松给药不影响人类对 d-苯丙胺的主观反应。
DOI：
10.1007/s002130000599
复制
发表时间：
2001
影响因子：
3.4
通讯作者：
deWit,H
中科院分区：
文献类型：
--
作者：
Wachtel,SR;Charnot,A;deWit,H
理由：压力和糖皮质激素促进和恢复啮齿类动物的精神兴奋剂自我给药。然而，压力和糖皮质激素对精神兴奋剂的主观和行为影响的影响尚未在人类中得到充分研究。目的：检查急性氢化可的松预处理对 d-苯丙胺的主观和行为影响的影响。方法：在安慰剂对照的四次疗程中，向 16 名健康男性和女性志愿者口服氢化可的松 (100 mg) 和 d-苯丙胺 (20 mg)，主题内、交叉设计。为了防止胃部刺激，受试者在每次实验前服用盐酸雷替丁。依赖性测量包括自我报告的情绪和主观影响（成瘾研究中心清单、情绪状态概况和一系列视觉模拟量表）、生命体征、唾液皮质醇和精神运动表现。结果：氢化可的松升高唾液皮质醇水平，产生适度的烦躁不安，并减少受试者想要更多药物的报告。然而，氢化可的松预处理不会影响 d-苯丙胺的任何生理、行为或主观作用。 结论：与啮齿动物研究中糖皮质激素的作用相反，这些结果表明皮质醇的急剧增加不会增强 d-苯丙胺对人类的精神兴奋作用。
Rationale:Stress and glucocorticoids facilitate and reinstate psychostimulant self-administration in rodents. However, the effects of stress and glucocorticoids on the subjective and behavioral effects of psychostimulants have not been well studied in humans.Objectives:To examine the effects of acute hydrocortisone pretreatment on the subjective and behavioral effects ofd-amphetamine.Methods:Hydrocortisone (100 mg) andd-amphetamine (20 mg) were administered orally to 16 healthy male and female volunteers in a four-session, placebo-controlled, within-subject, crossover design. To prevent stomach irritation, subjects received rantidine hydrochloride before each experimental session. Dependent measures included self-reported mood and subjective effects (Addiction Research Center inventory, the profile of mood states, and a series of visual analogue scales), vital signs, salivary cortisol, and psychomotor performance.Results:Hydrocortisone elevated salivary cortisol levels, produced modest dysphoria, and reduced subjects' reports of wanting more drug. However, hydrocortisone pretreatment did not affect any of the physiological, behavioral, or subjective effects ofd-amphetamine.Conclusions:In contrast to the effects of glucocorticoids in rodent studies, these results indicate that an acute increase in cortisol does not enhance the psychostimulant effects ofd-amphetamine in humans.