Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors
Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors
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DOI：
10.1042/bst0280785
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发表时间：
2000-12-01
影响因子：
3.9
通讯作者：
Lichtenthaler, HK
中科院分区：
文献类型：
--
作者：
Lichtenthaler, HK
描述了植物异戊烯基二磷酸和类异戊二烯生物合成的非甲羟戊酸新途径的基本步骤。这种1-脱氧-D-木酮糖5-磷酸/2-C-甲基-D-β 4-磷酸（DOXP/MEP）途径的前五种酶和基因是已知的。除草剂磷咪霉素特异性地阻断第二种酶，DOXP还原异构酶。DOXP/MEP途径也存在于几种病原菌和疟原虫中。因此，在植物中阻断这种新的类异戊二烯途径的所有除草剂和抑制剂也是对抗疟疾和由病原菌引起的疾病的潜在药物。
The essential steps of the novel non-mevalonate pathway of isopentenyl diphosphate and isoprenoid biosynthesis in plants are described. The first five enzymes and genes of this 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway are known. The herbicide fosmidomycin specifically blocks the second enzyme, the DOXP reductoisomerase. The DOXP/MEP pathway is also present in several pathogenic bacteria and the malaria parasite. Hence, all herbicides and inhibitors blocking this novel isoprenoid pathway in plants are also potential drugs against malaria and diseases caused by pathogenic bacteria.