FAMILIAL EMPIRICAL RISKS FOR INFLAMMATORY BOWEL-DISEASE - DIFFERENCES BETWEEN JEWS AND NON-JEWS
FAMILIAL EMPIRICAL RISKS FOR INFLAMMATORY BOWEL-DISEASE - DIFFERENCES BETWEEN JEWS AND NON-JEWS
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DOI：
10.1136/gut.34.4.517
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发表时间：
1993-04-01
期刊：
影响因子：
24.5
通讯作者：
ROTTER, JI
中科院分区：
文献类型：
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作者：
YANG, H;MCELREE, C;ROTTER, JI
与非犹太邻居相比，犹太人患炎症性肠病的频率增加。遗传因素已被牵连在这种疾病的病因，并可能有助于种族差异。本研究确定了炎症性肠病先证者（犹太人和非犹太人）一级亲属中炎症性肠病的家族经验风险，以进行准确的遗传咨询和遗传分析。来自南加州的527名炎症性肠病患者（291名犹太人和236名非犹太人）被问及他们的一级亲属（共2493人）是否患有炎症性肠病。由于炎症性肠病的发病年龄可变且较晚，因此使用年龄特异性发病率数据来估计终生风险，并在不同组之间进行有效比较。在非犹太先证者的一级亲属中，当先证者患有克罗恩病和溃疡性结肠炎时，炎症性肠病的终生风险分别为5.2%和1.6%。这些值始终低于犹太患者亲属的相应风险-克罗恩病和溃疡性结肠炎先证者分别为7.8%和4.5%（犹太人和非犹太人之间比较的p值：0-028;溃疡性结肠炎和克罗恩病之间：0.005）。这些数据为白色美国人群中这些疾病的遗传咨询提供了必要的基础。此外，犹太人和非犹太人先证者亲属的这些不同的经验风险允许拒绝炎性肠病的单孟德尔基因模型，但与几种替代遗传模型一致。
The Jewish population has an increased frequency of inflammatory bowel disease compared with their non-jewish neighbours. Genetic factors have been implicated in the aetiology of this disorder and may contribute to ethnic differences. This study determined the familial empirical risks for inflammatory bowel disease in the first degree relatives of inflammatory bowel disease probands (for both Jews and non-jews) for the purpose of accurate genetic counselling and genetic analysis. A total of 527 inflammatory bowel disease patients from Southern California (291 Jews and 236 non-jews) were questioned about inflammatory bowel disease in their first degree relatives (a total of 2493 individuals). Since inflammatory bowel disease has a variable and late age of onset, age specific incidence data were used to estimate the life time risks and to make valid comparisons between the different groups. In the first degree relatives of non-jewish probands, the life time risks for inflammatory bowel disease were 5.2% and 1.6% when probands had Crohn's disease and ulcerative colitis respectively. These values were consistently lower than the corresponding risks for relatives of Jewish patients - 7.8% and 4.5% for Crohn's disease and ulcerative colitis probands respectively (p value for comparison between Jews and non-jews: 0-028; between ulcerative colitis and Crohn's disease: 0.005). These data provide the requisite basis for genetic counselling for these disorders in the white American population. In addition, these different empirical risks for relatives of Jewish and non-jewish probands allow rejection of single Mendelian gene models for inflammatory bowel disease, but are consistent with several alternative genetic models.