Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving API2 and MALT1 and IGH and MALT1
Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving API2 and MALT1 and IGH and MALT1
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DOI：
10.1038/sj.leu.2403185
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发表时间：
2004-01-01
期刊：
影响因子：
11.4
通讯作者：
Dewald, GW
中科院分区：
文献类型：
--
作者：
Remstein, ED;Kurtin, PJ;Dewald, GW
API 2-MALT 1融合和非整倍体是MALT淋巴瘤中常见的染色体异常。在研究它们在原发性肺MALT淋巴瘤中的发病率和关系时，还确定了涉及MALT 1和IGH的易位。在所有，28原发性肺MALT淋巴瘤进行了研究，荧光原位杂交使用API 2-MALT 1探针和多个着丝粒探针，以及IGH-BCL 2，IGH-MALT 1，和MALT 1断裂探针在选定的情况下。七个（25%）有API 2-MALT 1融合，所有七个缺乏非整倍体，除了两个三体3在一个小克隆。3例（11%）有IGH-MALT 1融合; 2例还显示3三体和12三体。共有11例（39%）仅为非整倍体，其中3号三体和18号三体最常见。异位核bcl-10的表达，这已经与API 2-MALT 1，被认为是通过免疫组化在86%的API 2-MALT 1融合阳性的情况下，IGH-MALT 1融合阳性的情况下，两个非整倍体的情况下，和两个正常的情况下。在原发性肺MALT淋巴瘤中，细胞遗传学异常是常见的（75%）和异质性的，包括API 2-MALT 1和IGH-MALT 1，这是相互排斥的，以及非整倍体，这可能存在于后者，但在前者是罕见的。异位核bcl-10表达与API 2-MALT 1相关，但也可见于IGH-MALT 1融合阳性、仅非整倍体和正常病例。
API2-MALT1 fusion and aneuploidy are common chromosomal abnormalities in MALT lymphoma. In studying their incidence and relationship in primary pulmonary MALT lymphomas, a translocation involving MALT1 and IGH was also identified. In all, 28 primary pulmonary MALT lymphomas were studied by fluorescence in situ hybridization using an API2-MALT1 probe and multiple centromeric probes, as well as IGH-BCL2, IGH-MALT1, and MALT1 breakapart probes in selected cases. Seven (25%) had API2-MALT1 fusion; all seven lacked aneuploidy except for two with trisomy 3 in a small clone. Three (11%) had IGH-MALT1 fusion; two also showed trisomy 3 and 12. A total of 11 (39%) had aneuploidy only, with trisomy 3 and 18 being the most common. Ectopic nuclear bcl-10 expression, which has been previously associated with API2-MALT1, was seen by immunohistochemistry in 86% of API2-MALT1 fusion-positive cases, one IGH-MALT1 fusion-positive case, two aneuploidy-only cases, and two normal cases. In primary pulmonary MALT lymphomas, cytogenetic abnormalities are common (75%) and heterogeneous, encompassing API2-MALT1 and IGH-MALT1, which are mutually exclusive, as well as aneuploidy, which may be present in the latter but is rare in the former. Ectopic nuclear bcl-10 expression is associated with API2-MALT1 but may also be seen in IGH-MALT1 fusion-positive, aneuploidy-only, and normal cases.