ESTIMATION OF METABOLITE CONCENTRATIONS FROM LOCALIZED IN-VIVO PROTON NMR-SPECTRA
ESTIMATION OF METABOLITE CONCENTRATIONS FROM LOCALIZED IN-VIVO PROTON NMR-SPECTRA
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DOI：
10.1002/mrm.1910300604
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发表时间：
1993-12-01
影响因子：
3.3
通讯作者：
PROVENCHER, SW
中科院分区：
文献类型：
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作者：
PROVENCHER, SW
LCModel 方法将体内光谱分析为体外代谢物溶液模型光谱的线性组合。通过使用完整的模型光谱，而不仅仅是单个共振，最大的信息和独特性被纳入分析中。约束正则化方法考虑了体外和体内光谱之间的相位、基线和线形差异，并估计代谢物浓度及其不确定性。 LCModel 是全自动的，因为唯一的输入是时域体内数据。缺乏主观互动应该有助于结果的交流和比较。使用 LCModel 分析了来自患者和健康志愿者的 3000 多个人脑 STEAM 光谱。可以可靠地测定 N-乙酰天冬氨酸、胆碱、肌酸、肌醇和谷氨酸，这些物质的异常水平或乳酸、丙氨酸、苯乙烯肌醇、谷氨酰胺或葡萄糖水平的升高清楚地表明多种病理。将提供计算机程序。
The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model spectra of metabolite solutions in vitro. By using complete model spectra, rather than just individual resonances, maximum information and uniqueness are incorporated into the analysis. A constrained regularization method accounts for differences in phase, baseline, and lineshapes between the in vitro and in vivo spectra, and estimates the metabolite concentrations and their uncertainties. LCModel is fully automatic in that the only input is the time-domain in vivo data. The lack of subjective interaction should help the exchange and comparison of results. More than 3000 human brain STEAM spectra from patients and healthy volunteers have been analyzed with LCModel. N-acetylaspartate, cholines, creatines, myo-inositol, and glutamate can be reliably determined, and abnormal levels of these or elevated levels of lactate, alanine, sryllo-inositol, glutamine, or glucose clearly indicate numerous pathologies. A computer program will be available.