FORMATION OF 8-HYDROXYGUANINE RESIDUES IN CELLULAR DNA EXPOSED TO THE CARCINOGEN 4-NITROQUINOLINE 1-OXIDE
FORMATION OF 8-HYDROXYGUANINE RESIDUES IN CELLULAR DNA EXPOSED TO THE CARCINOGEN 4-NITROQUINOLINE 1-OXIDE
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DOI：
10.1016/s0006-291x(86)80036-5
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发表时间：
1986-09-01
影响因子：
3.1
通讯作者：
KAWAZOE, Y
中科院分区：
文献类型：
--
作者：
KOHDA, K;TADA, M;KAWAZOE, Y
在致癌物4-硝基喹啉-1-氧化物作用下，艾氏腹水细胞DNA中形成8-羟基鸟嘌呤(8-OH-Gua)残基。小牛胸腺DNA与该致癌物的最近代谢物4-羟氨基-1-氧化物与一磷酸丝氨酸腺苷一起化学处理，证实了8-OH-GUA的形成。8-羟基-瓜氨酸与喹啉键合加合物的生成速率之比约为0.2~0.3。提出了一种可能的8-羟基-瓜氨酸形成机理。
8-Hydroxyguanine (8-OH-Gua) residues were formed in DNA of Ehrlich ascites cells exposed to the carcinogen 4-nitroquinoline 1-oxide. Formation of 8-OH-Gua was confirmed by chemical treatment of calf thymus DNA with the proximate metabolite of this carcinogen, 4-hydroxyaminoguinoline 1-oxide, together with seryl-adenosine monophosphate. The ratio of the rates of formations of 8-OH-Gua and the quinoline-bound adducts was about 0.2-0.3. A conceivable mechanism of formation of 8-OH-Gua is proposed.