Association of variants in microRNA with Parkinson's disease in Chinese Han population
Association of variants in microRNA with Parkinson's disease in Chinese Han population
复制标题
microRNA变异与中国汉族人群帕金森病的关联
DOI：
10.1007/s10072-017-3210-4
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发表时间：
2018
影响因子：
3.3
通讯作者：
Xu Yuming
中科院分区：
文献类型：
--
作者：
Li Fang;Liu Han;Cheng Yuan;Yang Jing;Liu Yutao;Wang Yanlin;Yang Zhihua;Shi Changhe;Xu Yuming
MicroRNAs(MiRNAs)是调节基因表达的短RNA，可能参与多种疾病的发病机制。最近发现miR-4519中的rs897984：T >； C和miR-548at-5p中的rs11651671：A >； G与帕金森病(PD)相关。然而，据我们所知，没有关于这一发现的进一步证据。在此，我们对546名PD患者和550名健康对照进行了一项病例对照研究，以确定两个单核苷酸多态(SNPs)的基因型，以评估它们与PD的相关性。结果显示，MIR-4519中rs897984(C等位基因OR值= 0.851，95%CI 0.603~1.201，P= 0.358)和MIR-548at-5p中rs11651671(G等位基因OR值= 1.405，95%CI 0.927~2.131，P= 0.107)与帕金森病无关联，提示它们可能不是中国汉族人群帕金森病的易感基因。要阐明miRNAs与帕金森病之间的联系，还需要更多来自更大样本量和其他种族人群的证据。
MicroRNAs (miRNAs) are short RNAs regulating gene expression and may participate in pathogenesis of various diseases. Recently, rs897984:T > C in miR-4519 and rs11651671:A > G in miR-548at-5p have been reported that associate with Parkinson’s disease (PD). However, to our knowledge, there is no further evidence regarding this finding. Herein, we performed a case-control study of 546 PD patients and 550 healthy controls to genotype the two single-nucleotide polymorphisms (SNPs) to assess their associations with PD. The results showed that rs897984 (OR value for C allele = 0.851, 95% CI 0.603–1.201,P= 0.358) in miR-4519 and rs11651671 (OR value for G allele = 1.405, 95% CI 0.927–2.131,P= 0.107) in miR-548at-5p were not associated to PD, which suggest they may not contribute to the gene susceptibility of PD at least in Chinese Han population. More evidences from larger sample size and other ethnic populations are still needed to illustrate the association between miRNAs and PD.