HORMONAL PATTERN IN PROSTATIC-CANCER .2. CORRELATION WITH PRIMARY RESPONSE TO ENDOCRINE TREATMENT
HORMONAL PATTERN IN PROSTATIC-CANCER .2. CORRELATION WITH PRIMARY RESPONSE TO ENDOCRINE TREATMENT
复制标题
DOI：
10.1530/acta.0.0980634
复制
发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
KARONEN, SL
中科院分区：
文献类型：
--
作者：
ADLERCREUTZ, H;RANNIKKO, S;KARONEN, SL
在 32 名经组织学和/或细胞学证实患有前列腺癌的受试者中，通过测定 18 种血浆和尿液激素或激素组并将这些值与内分泌治疗的反应联系起来，研究了激素模式。 9 例患者接受了全睾丸切除术（睾丸附睾切除术），13 例患者接受了包膜下睾丸切除术，4 例患者接受了雌激素治疗。六名患者接受了全睾丸切除术，随后进行了雌激素治疗。除少数例外，所有值均在正常范围内。与在工厂工作的健康男性相比，唯一显着的例外是尿雌激素值高和尿雌酮+雌二醇/雌三醇比率低。尿激素值或激素值比值不能用于预测前列腺癌患者的预后。然而，血浆睾酮/雌二醇（T/E2）和睾酮/催乳素（T/Prl）的比率提供了有关内分泌治疗反应的良好信息。这些比率中的一个或两个的高值意味着所有受试者对治疗都有良好的反应，在本材料中无一例外。两个比率均较低的受试者中有 50% 的病例对内分泌治疗有良好反应。测量的其他血浆激素对预后没有任何帮助。通过测量T/E2和T/Prl比率，可以选择对内分泌治疗具有良好主要反应的一组患者。
In 32 subjects with histologically and/or cytologically verified prostatic cancer the hormonal pattern was studied by assaying 18 plasma and urinary hormones or groups of hormones and relating the values to the response to endocrine treatment. Total orchiectomy (orchiepididymectomy) was performed on 9 patients, subcapsular orchiectomy on 13 patients and estrogen therapy with Estradurin was given in 4 patients. Six patients had total orchiectomy followed by estrogen therapy. With few exceptions all values were within the normal range. The only significant exceptions were the high urinary estrogen values and the low urinary estrone + estradiol/estriol ratio observed as compared to healthy males working in a factory. No urinary hormone values or ratios of hormone values could be used for the prediction of prognosis in prostatic carcinoma patients. However, the ratios of plasma testosterone/estradiol (T/E2) and testosterone/prolactin (T/Prl) gave good information with regard to the response to endocrine treatment. High values for 1 or both of these ratios meant a good response to treatment in all subjects without exception in this material. Subjects with both ratios low had a good response to endocrine treatment in 50% of the cases. No other plasma hormones measured were of any help prognostically. By measuring the T/E2 and T/Prl ratios a group of patients with favorable primary response to endocrine treatment may be selected.