Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance
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DOI：
10.1152/ajpendo.00117.2003
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发表时间：
2003-10-01
影响因子：
5.1
通讯作者：
Kalhan, SC
中科院分区：
文献类型：
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作者：
Kelley, DE;McKolanis, TM;Kalhan, SC
目前的研究旨在检查 2 型糖尿病 (DM) 患者脂肪肝代谢和身体成分的相关性。 83 名患有 2 型糖尿病 [平均体重指数 (BMI)：34+/-0.5 kg/m(2)] 且无肝功能障碍临床或实验室证据的男性和女性进行了脂肪量 (FM)、内脏脂肪组织 (VAT)、肝脏和脾脏计算机断层扫描 (CT) 衰减（肝脏与脾脏的比率）、肌肉 CT 的身体成分评估 衰减和大腿肥胖；这些评估也在 12 名瘦弱和 15 名肥胖的非糖尿病志愿者中进行。胰岛素敏感性通过正常血糖胰岛素输注（40 mU.m(-2).min(-1)）结合全身间接量热法来测量，以评估葡萄糖和脂质氧化，并通过输注[H-2(2)]葡萄糖来评估内源性葡萄糖的产生。大多数 2 型糖尿病患者 (63%) 符合脂肪肝 CT 标准，而肥胖志愿者的这一比例为 20%，瘦身非糖尿病志愿者则没有。脂肪肝与增值税的相关性最强（r=-0.57，P
The current study was undertaken to examine metabolic and body composition correlates of fatty liver in type 2 diabetes mellitus (DM). Eighty-three men and women with type 2 DM [mean body mass index (BMI): 34+/-0.5 kg/m(2)] and without clinical or laboratory evidence of liver dysfunction had body composition assessments of fat mass (FM), visceral adipose tissue (VAT), liver and spleen computed tomography (CT) attenuation (ratio of liver to spleen), muscle CT attenuation, and thigh adiposity; these assessments were also performed in 12 lean and 15 obese nondiabetic volunteers. Insulin sensitivity was measured with a euglycemic insulin infusion (40 mU.m(-2).min(-1)) combined with systemic indirect calorimetry to assess glucose and lipid oxidation, and with infusions of [H-2(2)] glucose for assessment of endogenous glucose production. A majority of those with type 2 DM (63%) met CT criteria for fatty liver, compared with 20% of obese and none of the lean nondiabetic volunteers. Fatty liver was most strongly correlated with VAT (r=-0.57, P