Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
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DOI：
10.1038/s41593-019-0569-y
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发表时间：
2020-01-06
影响因子：
25
通讯作者：
Briggs, John A. G.
中科院分区：
文献类型：
--
作者：
Erlendsson, Simon;Morado, Dustin R.;Briggs, John A. G.
Arc 是一种对突触可塑性至关重要的神经元基因，起源于逆转录转座子 Gag 基因的驯化，介导细胞间信使 RNA 转移。我们报告了由果蝇 dArc1 和 dArc2 形成的逆转录病毒样衣壳的高分辨率结构，这些衣壳具有表面刺突和假定的内部 RNA 结合域。这些数据表明，Arc 的病毒样衣壳形成特性在进化上是保守的，并为理解它们在细胞间通讯中的功能提供了结构基础。
Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.