Universal method for fabricating PDMS microfluidic device using SU8, 3D printing and soft lithography
Universal method for fabricating PDMS microfluidic device using SU8, 3D printing and soft lithography
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DOI：
10.1142/s2339547820500041
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发表时间：
2020-03-01
期刊：
影响因子：
--
通讯作者：
Basuray, Sagnik
中科院分区：
文献类型：
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作者：
Chande, Charmi;Riaz, Nida;Basuray, Sagnik
微流控装置由聚二甲基硅氧烷（PDMS）构建，因为它们具有生物相容性，制造容易，完善的协议和简单性。基于PDMS的微流控装置是通过(i)将液态PDMS应用于负模（通常是硅或3d打印模具）和（ii）在设定的时间内加热固化PDMS来构建的。3d打印模具中未反应的树脂单体阻碍了PDMS的完全固化，导致PDMS内部通道形成不当，降低了PDMS器件的功效。内部协议使用SU-8作为3d打印模具上的“不粘”涂层，促进了PDMS的成功铸造。接触角、表面轮廓、光学轮廓和力测试证明，由su -8处理过的模具铸造的PDMS与未经处理的模具铸造的PDMS不同，与原始PDMS相似。此外，该方法推广到使用不同3D打印树脂的商业3D打印。为了证明该技术在微流控设备中的可行性，使用经过处理的3D打印的PDMS的微流控树显示出鲜艳的颜色和清晰的线条。未经处理的PDMS不存在这种情况。
Microfluidic devices are constructed from polydimethylsiloxane (PDMS) due to their biocompatibility, fabrication ease, well-established protocols, and simplicity. PDMS-based microfluidic devices are constructed by (i) applying liquid PDMS to a negative mold (usually a silicon or 3D-printed mold) and (ii) curing the PDMS with heat exposure over a set time period. Unreacted resin monomers in 3D-printed molds prevent PDMS from fully curing, resulting in improper channel formation in PDMS and reducing the PDMS device's efficacy. An in-house protocol that uses SU-8 as a "non-stick" coating on 3D-printed molds facilitates the successful casting of PDMS. Contact angle, surface profile, optical profile, and force testing prove that PDMS cast from SU-8-treated molds resembles pristine PDMS, unlike PDMS cast from untreated molds. Further, this method is generalized to commercial 3D prints using different 3D printing resins. To demonstrate this technique's viability in microfluidic devices, a microfluidic tree using PDMS from treated 3D prints shows vibrant colors and clear lines. This is absent from an untreated PDMS.