Are There Differences in Brain Morphology in Patients with Lifelong Premature Ejaculation?
Are There Differences in Brain Morphology in Patients with Lifelong Premature Ejaculation?
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DOI：
10.1016/j.jsxm.2019.04.008
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发表时间：
2019-07-01
影响因子：
3.5
通讯作者：
Canat, Lutfi
中科院分区：
文献类型：
--
作者：
Atalay, Hasan Anil;Sonkaya, Ali Riza;Canat, Lutfi
简介：即使终身早泄（PE）是非常普遍的，很少有研究调查的神经机制PE.Aim：本研究的目的是探讨是否与终身PE患者表现出宏观或微观结构的改变，参与男性sexual response.Materials和方法的大脑部分：我们招募了42名健康参与者和54终身PE患者。根据早泄诊断工具（PEDT）和阴道内射精潜伏时间（IELT）诊断终身PE。我们使用全脑T1加权磁共振成像的基于体素的形态测量方法比较了两组之间的皮质形态测量，如灰质体积、白色物质体积、小脑体积和皮质下结构（即杏仁核、尾状核、海马、苍白球、壳核和丘脑）。此外，我们通过自报问卷调查评估了相关脑改变与参与者症状严重程度之间的关系。主要结果测量：评估了PE患者和对照组的脑宏观和微观结构改变，沿着PE患者尾状核改变与临床数据的相关性结果：与健康对照组相比，终身PE患者的尾状核平均体积显著更大（P = 0.048）。此外，尾状核体积与PEDT评分呈正相关（r 1/4 0.621; P = .0179），与IELT呈负相关（r = -0.592; P = .0101）。然而，皮质形态学和其他皮质下体积没有显着差异2 groups.Clinical意义：在深灰质核团的微结构改变可能是一个有用的参数，研究机制的神经生物学基础PE.Strengths和局限性：有少数研究探讨PE患者的微结构变化。这项研究进一步加深了我们对PE病因的理解。局限性包括小样本，这限制了我们的能力，以绝对确定这种皮层下的变化是否是终身PE的原因或后果。结论：我们发现PE患者和健康对照组之间的尾状核体积有显着差异。此外，尾状核体积与PE症状的严重程度呈正相关。需要更广泛的和可能的纵向研究，以提高我们对PE的神经生物学机制的理解。版权所有（C）2019，国际性医学学会。爱思唯尔公司出版All rights reserved.
Introduction: Even though lifelong premature ejaculation (PE) is highly prevalent, few studies have investigated the neural mechanisms underlying PE.Aim: This study aimed to investigate whether patients with lifelong PE exhibit macrostructural or microstructural alterations of the parts of the brain involved in the male sexual response.Materials and Methods: We enrolled 42 healthy participants and 54 lifelong PE patients. Lifelong PE was diagnosed according to the Premature Ejaculation Diagnostic Tool (PEDT) and intravaginal ejaculation latency time (IELT). We compared measures of cortical morphology, such as volumes of gray matter, white matter, cerebellum volumes, and subcortical structures (ie, amygdala, caudate, hippocampus, globus pallidus, putamen, and thalamus) between the groups using a voxel-based morphometry method from whole-brain T1-weighted magnetic resonance imaging. Moreover, we evaluated the relationships between the relevant cerebral alterations and the severity of symptoms obtained from participants via self-reported questionnaires.Main Outcome Measures: Cerebral macrostructural and microstructural alterations were assessed in PE patients and controls, along with the correlation of caudate nucleus changes in PE patients with clinical data (including the PEDT and the IELT).Results: The mean volume of the caudate nucleus was significantly larger in the lifelong PE patients compared with healthy controls (P = .048). Moreover, caudate nucleus volume was positively correlated with PEDT score (r 1/4 0.621; P = .0179) and negatively correlated with the IELT (r = -0.592; P = .0101). However, cortex morphology and the other subcortical volumes were not significantly different between the 2 groups (P >.05).Clinical Implications: Microstructural alterations in deep gray matter nuclei might be a useful parameter for studying the mechanism of the neurobiology underlying PE.Strengths and Limitations: There are few studies examining microstructural changes in PE patients. This study furthers our understanding of the etiology of PE. Limitations include the small sample, which limits our ability to make an absolute determination as to whether such subcortical changes are the cause or the consequence of lifelong PE.Conclusions: We found a significant difference in caudate nucleus volume between patients with PE and healthy controls. In addition, the caudate nucleus volume was positively associated with the severity of PE symptoms. More extensive and possibly longitudinal studies are needed to improve our understanding of the mechanism of the neurobiology underlying PE. Copyright (C) 2019, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.