Thrombocytopenia in acute leukaemia patients treated with IL2: cytolytic effect of LAK cells on megakaryocytic progenitors
Thrombocytopenia in acute leukaemia patients treated with IL2: cytolytic effect of LAK cells on megakaryocytic progenitors
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IL2治疗的急性白血病患者出现血小板减少症：LAK细胞对巨核细胞祖细胞的溶细胞作用
DOI：
10.1111/j.1365-2141.1991.tb08054.x
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发表时间：
1991
影响因子：
6.5
通讯作者：
R. Foà
中科院分区：
文献类型：
--
作者：
A. Guarini;F. Sanavio;A. Novarino;A. Tos;M. Aglietta;R. Foà
In vivo administration of recombinant interleukin 2 (IL2) has been associated, in acute leukaemia as well as in other tumours, with a variable degree of thrombocytopenia. In two patients with acute myeloid leukaemia who showed a progressive and severe fall in platelet count during daily continuous i. v. infusion of IL2, we assessed whether peripheral blood IL2‐generated lymphokine activated killer (LAK) lymphocytes could affect growth of the autologous bone marrow megakaryocytic progenitor cell compartment (CFU‐MK) in vitro. Following overnight pre‐incubation in liquid culture of the marrow cells with autologous LAK effectors, there was an almost complete abrogation of the CFU‐MK colony growth (97% and 89% inhibition). Pre‐incubation in the presence of a monoclonal antibody to tumour necrosis factor alpha (TNF) completely reversed the inhibitory effect. The role played by TNF was confirmed by the finding that recombinant TNF caused a dose‐dependent inhibition of the growth of CFU‐MK. IL2 alone was ineffective. These results suggest that the often severe thrombocytopenia observed in patients with acute leukaemia treated with IL2 is at least partly due to autologous LAK cells activated in vivo following the administration of IL2.
通过持续输注使用白细胞介素 2 进行免疫治疗期间出现血小板减少症。
DOI：
10.1016/0002-9343(90)90343-c
发表时间：
1990
期刊：
The American journal of medicine
影响因子：
--
作者：
Paciucci,PA;Mandeli,J;Oleksowicz,L;Ameglio,F;Holland,JF
通讯作者：
Holland,JF
在用白细胞介素 2 培养物中诱导针对新鲜人白血病的 NK 细胞活性。
DOI：
--
发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lotzová,E;Savary,CA;Herberman,RB
通讯作者：
Herberman,RB
肿瘤坏死因子：造血细胞上的受体。
影响因子：
20.3
作者：
Munker,R;DiPersio,J;Koeffler,HP
通讯作者：
Koeffler,HP