circ_100984-miR-432-3p axis regulated c-Jun/YBX-1/β-catenin feedback loop promotes bladder cancer progression.
circ_100984-miR-432-3p axis regulated c-Jun/YBX-1/β-catenin feedback loop promotes bladder cancer progression.
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DOI：
10.1111/cas.14774
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发表时间：
2021-04
期刊：
影响因子：
5.7
通讯作者：
Qi L
中科院分区：
文献类型：
--
作者：
Tong L;Yang H;Xiong W;Tang G;Zu X;Qi L
膀胱癌（BC）是全球最常见的癌症之一。近年来，研究发现环状RNA（circRNA）以多种机制参与了乳腺癌的发生发展。然而，尚未确定BC中的circ_100984的机制。在这里，我们发现circ_100984和YBX-1在BC中高表达，而miR-432 - 3 p在BC中低表达。circ_100984和YBX-1的沉默在体外和体内抑制BC肿瘤生长、迁移和侵袭。从机制上讲，我们揭示了circ_100984作为一种竞争性内源性RNA，吸收miR-432 - 3 p间接调节YBX-1和上皮-间质转化（EMT）相关分子。此外，我们证实YBX-1或c-Jun分别在BC细胞中作为β-catenin或YBX-1的转录调节因子。敲低YBX-1抑制β-catenin和c-Jun的表达，而下调c-Jun则相反地抑制YBX-1和β-catenin的表达。我们的研究结果表明，circ_100984-miR-432 - 3 p轴调控的c-Jun/YBX-1/β-catenin反馈环促进BC进展，为BC进展提供了潜在的治疗轴。circ_100984海绵状miR-432 - 3 p形成c-Jun/YBX-1/β-catenin反馈环并促进膀胱癌进展，为BC进展提供潜在的治疗轴。
Bladder cancer (BC) is one of the most commonly diagnosed cancers globally. Recently, circular RNAs (circRNAs) have been revealed to participate in BC progression with diverse mechanisms. However, mechanisms of circ_100984 in BC have not been determined. Here, we found that circ_100984 and YBX‐1 were high presented, while miR‐432‐3p was low presented in BC. Silencing of circ_100984 and YBX‐1 repressed BC tumor growth, migration, and invasion in vitro and in vivo. Mechanistically, we revealed that circ_100984 served as a competing endogenous RNA that sponged miR‐432‐3p to indirectly regulate YBX‐1 and epithelial‐mesenchymal transition (EMT)‐related molecules. Moreover, we confirmed that YBX‐1 or c‐Jun acted as a transcription regulatory factor for β‐catenin or YBX‐1, respectively, in BC cells. Knockdown of YBX‐1 inhibited the expression of β‐catenin and c‐Jun, whereas downregulated c‐Jun inversely repressed the expression of YBX‐1 and β‐catenin. Our results suggested that circ_100984‐miR‐432‐3p axis regulated c‐Jun/YBX‐1/β‐catenin feedback loop promotes BC progression, providing a potential therapeutic axis for BC progression. circ_100984 sponges miR‐432‐3p to form c‐Jun/YBX‐1/β‐catenin feedback loop and promotes bladder cancer progression, providing a potential therapeutic axis for BC progression.
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