Prolactin Receptor Expression and Breast Cancer: Relationships with Tumor Characteristics among Pre- and Post-menopausal Women in a Population-Based Case-Control Study from Poland
Prolactin Receptor Expression and Breast Cancer: Relationships with Tumor Characteristics among Pre- and Post-menopausal Women in a Population-Based Case-Control Study from Poland
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DOI：
10.1007/s12672-013-0165-7
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发表时间：
2014-02-01
影响因子：
3
通讯作者：
Figueroa, Jonine D.
中科院分区：
文献类型：
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作者：
Faupel-Badger, Jessica M.;Duggan, Maire A.;Figueroa, Jonine D.
先前的研究发现，循环催乳素水平升高与乳腺癌风险增加之间存在关联。催乳素通过与细胞表面催乳素受体结合，刺激乳腺癌细胞增殖、迁移和存活。催乳素受体表达与乳腺肿瘤发生的关系尚不清楚，因为集中于这种关系的研究样本量和/或肿瘤特征信息有限。在这里，我们研究了736例催乳素表达与肿瘤特征的关系，这些病例来自波兰（2000-2003年）进行的一项基于人群的乳腺癌病例对照研究，并提供了详细的危险因素和病理数据。对肿瘤进行集中审查并制备组织微阵列，用于催乳素受体表达的免疫组织化学分析。利用chi(2)分析和logistic回归评估不同肿瘤特征层催乳素受体表达的相关性。催乳素受体的表达不随绝经状态而变化；因此，来自绝经前和绝经后妇女的数据被合并在分析中。大约83%的乳腺癌被归类为强催乳素受体染色。催乳素受体表达阴性/低与低分化肿瘤（p = 1.2 × 10(-08)）和较大肿瘤（p = 0.0005）独立相关。这些关联与雌激素受体的表达无关。这是迄今为止规模最大的研究，其中评估了催乳素受体表达与肿瘤特征的关系。这些数据为探索催乳素/催乳素受体信号网络与乳腺肿瘤发生的关系提供了新的途径。
Previous studies have found an association between elevated circulating prolactin levels and increased risk of breast cancer. Prolactin stimulates breast cancer cell proliferation, migration, and survival via binding to the cell-surface prolactin receptor. The association of prolactin receptor expression with breast tumorigenesis remains unclear as studies that have focused on this association have had limited sample size and/or information about tumor characteristics. Here, we examined the association of prolactin expression with tumor characteristics among 736 cases, from a large population-based case-control study of breast cancer conducted in Poland (2000-2003), with detailed risk factor and pathology data. Tumors were centrally reviewed and prepared as tissue microarrays for immunohistochemical analysis of prolactin receptor expression. Association of prolactin receptor expression across strata of tumor characteristics was evaluated using chi (2) analysis and logistic regression. Prolactin receptor expression did not vary by menopausal status; therefore, data from pre- and post-menopausal women were combined in the analyses. Approximately 83 % of breast cancers were categorized as strong prolactin receptor staining. Negative/low prolactin receptor expression was independently associated with poorly differentiated (p = 1.2 x 10(-08)) and larger tumors (p = 0.0005). These associations were independent of estrogen receptor expression. This is the largest study to date in which the association of prolactin receptor expression with tumor characteristics has been evaluated. These data provide new avenues from which to explore the associations of the prolactin/prolactin receptor signaling network with breast tumorigenesis.