DIET AND NASOPHARYNGEAL CARCINOMA - A CASE-CONTROL STUDY IN GUANGZHOU, CHINA
DIET AND NASOPHARYNGEAL CARCINOMA - A CASE-CONTROL STUDY IN GUANGZHOU, CHINA
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DOI：
10.1002/ijc.2910430621
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发表时间：
1989-06-15
影响因子：
6.4
通讯作者：
HENDERSON, BE
中科院分区：
文献类型：
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作者：
YU, MC;HUANG, TB;HENDERSON, BE
我们对306例经组织学证实的鼻咽癌（NPC）病例进行了访谈，这些病例发生在中国广州市，年龄在50岁以下，以及相同数量的年龄、性别和社区匹配的对照组。我们还采访了110名45岁以下患者的母亲和139名对照患者的母亲，这些母亲与45岁以下的患者相匹配，以获得研究对象的儿童暴露信息。无论是在成年期还是儿童期，接触咸鱼都与鼻咽癌风险增加显著相关。断奶期间的暴露与鼻咽癌风险的相关性最强，在调整了断奶期间的暴露后，所有其他时期的暴露与鼻咽癌风险不再相关。除咸鱼外，儿童时期暴露于其他5种腌制食品（发酵鱼露、咸虾酱、腐乳和2种酸梅）与鼻咽癌发病有显著相关性，且与咸鱼暴露无关。最后，这些病例摄入的新鲜蔬菜和水果明显少于对照组，尤其是在幼儿时期，而这种差异并不能用他们对咸鱼和其他腌制食品的不同消费模式来解释。
We conducted interviews on 306 histologically confirmed incident cases of nasopharyngeal carcinoma (NPC) occurring in residents of Guangzhou City, China, who were under the age of 50 years, and an equal number of age‐, sex‐, and neighborhood‐matched controls. We also interviewed 110 mothers of patients under age 45 years and 139 mothers of controls who were matched to patients under age 45 years, to obtain information on childhood exposures of study subjects. Exposure to salted fish, whether in adulthood or in childhood, was significantly associated with an increased risk of NPC. The association was strongest for exposure during weaning, and exposures at all other periods were no longer related to NPC risk after adjustment for exposure during weaning. Besides salted fish, childhood exposure to 5 other preserved foods (fermented fish sauce, salted shrimp paste, moldy bean curd, and 2 kinds of preserved plum) was significantly related to NPC, and the effects were independent of salted fish exposure. Finally, cases ingested significantly less fresh vegetables and fruits than controls, especially during early childhood, and the differences were not explained by their differing consumption pattern of salted fish and other preserved foods.