Identification of Bond-Weakening Spirosilane Catalyst for Photoredox α-C-H Alkylation of Alcohols
Identification of Bond-Weakening Spirosilane Catalyst for Photoredox α-C-H Alkylation of Alcohols
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DOI：
10.1002/adsc.201901253
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发表时间：
2019-12-04
影响因子：
5.4
通讯作者：
Kanai, Motomu
中科院分区：
文献类型：
--
作者：
Sakai, Kentaro;Oisaki, Kounosuke;Kanai, Motomu
催化剂控制的位点选择性C(sp(3)) - H官能化的发展是当前有机合成中的一个重大挑战。本文描述了通过密度泛函理论（DFT）指导鉴定出五价硅酸盐物种作为一种新型的醇的α - C - H键弱化催化剂，同时还使用了光氧化还原催化剂和氢原子转移催化剂。具体而言，马丁的螺硅烷加速了醇的α - C - H烷基化反应。
The development of catalyst-controlled site-selective C(sp(3))-H functionalization is a current major challenge in organic synthesis. This paper describes DFT-guided identification of pentavalent silicate species as a novel bond-weakening catalyst for the alpha-C-H bonds of alcohols together with a photoredox catalyst and a hydrogen atom transfer catalyst. Specifically, Martin's spirosilane accelerated alpha-C-H alkylation of alcohols.