Optimal dose of 18F-FDG required for whole-body PET using an LSO PET camera
Optimal dose of 18F-FDG required for whole-body PET using an LSO PET camera
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DOI：
10.1007/s00259-003-1317-8
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发表时间：
2003-12-01
影响因子：
9.1
通讯作者：
Franken, PR
中科院分区：
文献类型：
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作者：
Everaert, H;Vanhove, C;Franken, PR
减少全身氟-18-氟脱氧葡萄糖正电子发射断层扫描（F-18-FDG PET）（衰减校正）的采集时间在临床实践中具有重要意义。随着氧硅酸镥（LSO）的引入，如果患者注射了大量的示踪剂和/或系统在3D模式下运行，则可以显著缩短采集时间。本研究的目的是确定所需的F-18-FDG的最佳剂量，以实现良好到优秀的图像质量时，“3分钟发射，2分钟传输/床位置”协议用于LSO PET相机。回顾性评价了总共218项连续的全身F-18-FDG PET研究。排除肝转移、高血脂和静脉旁注射患者后，最终研究人群包括186例受试者（112例男性，74例女性，年龄59 - 15岁）。患者注射18F-FDG的活性范围为2.23至15.21 MBq/kg。在示踪剂施用后60分钟，用LSO PET照相机（Ecat Accel，Siemens）获取针对衰减校正的全身图像（3分钟发射，2分钟透射/床位置）。患者的手臂沿着身体定位。迭代地进行图像重建，并应用重建后滤波器。图像质量由两名独立观察员使用五点评分量表（差、合理、好、非常好、优秀）进行视觉评分。此外，在肝脏上的感兴趣区域中测量变异系数（COV），以量化噪声。在118例18F-FDG注射量大于或等于8 MBq/kg的患者中，观察者I和观察者2分别将92%和90%的图像分类为良好、非常好或极好。当使用LSO PET摄像机并应用3分钟发射、2分钟传输/床位采集协议时，剂量大于或等于8 MBq/kg的COV平均为10.63%+/-3.19%，剂量= 8 MBq/kg的COV平均为16.46%+/-5.14%，在绝大多数患者中获得了良好至极佳质量的图像。在较低剂量下，观察到图像质量迅速下降和噪声增加。应采用替代方案，以补偿剂量时图像质量的损失
Reducing the acquisition time of whole-body fluorine-18 fluorodeoxyglucose positron emission tomography (F-18-FDG PET) (corrected for attenuation) is of major importance in clinical practice. With the introduction of lutetium oxyorthosilicate (LSO), the acquisition time can be dramatically reduced, provided that patients are injected with larger amounts of tracer and/or the system is operated in 3D mode. The aim of this study was to determine the optimal dose of F-18-FDG required in order to achieve good-to-excellent image quality when a "3-min emission, 2-min transmission/bed position" protocol is used for an LSO PET camera. A total of 218 consecutive whole-body F-18-FDG PET studies were evaluated retrospectively. After excluding patients with liver metastases, hyperglycaemia and paravenous injections, the final study population consisted of 186 subjects (112 men, 74 women, age 59 15 years). Patients were injected with an activity of 18F-FDG ranging from 2.23 to 15.21 MBq/kg. Whole-body images corrected for attenuation (3 min emission, 2 min transmission/bed position) were acquired with an LSO PET camera (Ecat Accel,Siemens) 60 min after tracer administration. Patients were positioned with their arms along the body. Image reconstruction was done iteratively and a post-reconstruction filter was applied. Image quality was scored visually by two independent observers using a five-point scoring scale (poor, reasonable, good, very good, excellent). In addition, the coefficient of variability (COV) was measured in a region of interest over the liver in order to quantify noise. Of the images obtained in 118 patients injected with greater than or equal to8 MBq/kg 18F-FDG, 92% and 90% were classified as good, very good or excellent by observer I and observer 2, respectively. The COV averaged 10.63%+/-3.19% for doses greater than or equal to8 MBq/kg and 16.46%+/-5.14% for doses = 8 MBq/kg results in images of good to excellent quality in the vast majority of patients when using an LSO PET camera and applying a 3-min emission, 2-min transmission/bed position acquisition protocol. At lower doses, a rapid decline in image quality and increasing noise are observed. Alternative protocols should be adopted in order to compensate for the loss in image quality when doses