Freeze-fracture studies of denervated and tenotomized rat muscle.
Freeze-fracture studies of denervated and tenotomized rat muscle.
复制标题
去神经和腱切断大鼠肌肉的冷冻骨折研究。
DOI：
10.1097/00005072-198503000-00003
复制
发表时间：
1985
影响因子：
3.2
通讯作者：
Fischbeck,KH
中科院分区：
文献类型：
--
作者：
Sirken,SM;Fischbeck,KH
研究了去神经和断腱对大鼠趾长伸肌冷冻断裂超微结构的影响。肌细胞膜的正交表和小窝的密度进行了分析。一个时期被发现长达30天的年龄，需要神经支配的发展和维护的正交表。老年动物的去神经对正交表的密度没有影响。各年龄组去神经后小窝密度均增加。肌腱切断术延迟了正常阵列的发育，但对小窝密度没有显著影响。从去神经支配的大鼠肌肉中获得的结果与在杜氏肌营养不良症患者的肌肉中观察到的结果相似。
We studied the effects of denervation and tenotomy on the freeze-fracture ultrastructure of rat extensor digitorum longus muscle. The muscle plasma membrane was analyzed for the density of orthogonal arrays and caveolae. A period was found up to 30 days of age where innervation is required for the development and maintenance of orthogonal arrays. Denervation of older animals had no effect on the density of orthogonal arrays. The caveolar density increased after denervation at all ages. Tenotomy delayed the development of normal arrays, but had no significant effect on caveolar density. The results obtained for neonatally denervated rat muscles are similar to those seen in the muscles of patients with Duchenne muscular dystrophy.