The Ubiquitin-Proteasome System in Apoptosis and Apoptotic Cell Clearance.
The Ubiquitin-Proteasome System in Apoptosis and Apoptotic Cell Clearance.
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泛素-蛋白酶体系统在细胞凋亡和凋亡细胞清除中的作用
DOI：
10.3389/fcell.2022.914288
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
泛素化（Ubiquitination）是蛋白质翻译后的一种重要修饰，是指泛素与底物的共价结合，参与蛋白质稳定性调节、DNA损伤修复、细胞凋亡等多种生物学过程。E3泛素连接酶是泛素途径中的重要酶，具有高度的底物特异性，精确地调节特定蛋白质的周转。作为程序性细胞死亡的最充分研究的形式之一，细胞凋亡在整个进化树中基本上是保守的。凋亡的最后关键阶段是专职和非专职吞噬细胞清除凋亡细胞。细胞凋亡和凋亡细胞清除对于多细胞生物体的正常发育、分化和生长至关重要，以及它们与各种炎症和免疫疾病的关联。在这篇综述中，我们讨论了泛素化和去泛素化在细胞凋亡和凋亡细胞清除中的作用。
Ubiquitination, a critical post-translational modification of proteins, refers to the covalent attachment of ubiquitin to the substrate and is involved in various biological processes such as protein stability regulation, DNA damage repair, and apoptosis, among others. E3 ubiquitin ligases are essential enzymes of the ubiquitin pathway with high substrate specificity and precisely regulate specific proteins’ turnover. As one of the most well-studied forms of programmed cell death, apoptosis is substantially conserved across the evolutionary tree. The final critical stage in apoptosis is the removal of apoptotic cells by professional and non-professional phagocytes. Apoptosis and apoptotic cell clearance are crucial for the normal development, differentiation, and growth of multicellular organisms, as well as their association with a variety of inflammatory and immune diseases. In this review, we discuss the role of ubiquitination and deubiquitination in apoptosis and apoptotic cell clearance.