Simultaneous coronary pressure and flow velocity measurements in humans - Feasibility, reproducibility, and hemodynamic dependence of coronary flow velocity reserve, hyperemic flow versus pressure slope index, and fractional flow reserve
Simultaneous coronary pressure and flow velocity measurements in humans - Feasibility, reproducibility, and hemodynamic dependence of coronary flow velocity reserve, hyperemic flow versus pressure slope index, and fractional flow reserve
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DOI：
10.1161/01.cir.94.8.1842
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发表时间：
1996-10-15
期刊：
影响因子：
37.8
通讯作者：
Wijns, W
中科院分区：
文献类型：
--
作者：
deBruyne, B;Bartunek, J;Wijns, W
为了在导管室评估冠状动脉病变的严重程度，已经提出了几种基于导丝的方法。本研究的目的是比较冠状动脉血流储备（CFVR）、瞬时充血舒张期速度-压力斜率指数（IHDVPS）和压力衍生心肌血流储备分数（FFR（myo））的可行性和可重复性。在15处狭窄中计算了（0.014英寸导丝）、CFVR、IHDVPS和FFR（myo）（13名患者）在以下四对条件下：（1）基线条件下两次;（2）在80和110 bpm心房起搏期间;（3）硝普钠静脉滴注前及滴注中;（4）多巴酚丁胺静脉滴注前及滴注中。共获得104次测量结果。在所有情况下都可以计算CFVR和FFR（myo）。仅79%的病例可计算IHDVPS。CFVR的平均值在两次基线测量之间和输注硝普钠期间没有变化，但从1.85 ± 0.41降至1.66 ± 0.45（P
Background To assess coronary lesion severity in the catheterization laboratory, several guide wire-based methods have been proposed. The purpose of the present study was to compare the feasibility and the reproducibility of coronary how velocity reserve (CFVR), instantaneous hyperemic diastolic velocity-pressure slope index (IHDVPS), and pressure-derived myocardial fractional flow reserve (FFR(myo)).Methods and Results From distal coronary pressure and flow velocity signals (0.014-in guide wires), CFVR, IHDVPS, and FFR(myo) were computed in 15 stenoses (13 patients) under the four following pairs of conditions: (1) twice under baseline conditions; (2) during atrial pacing at 80 and 110 bpm; (3) before and during intravenous infusion of nitroprusside; and (4) before and during intravenous infusion of dobutamine. A total of 104 measurements were obtained. Both CFVR and FFR(myo) could be calculated in all cases. IHDVPS could be calculated in only 79% of cases. The mean value of CFVR did not change between the two baseline measurements and during infusion of nitroprusside but decreased from 1.85+/-0.41 to 1.66+/-0.45 (P