Investigating the association between COVID-19 vaccination and care home outbreak frequency and duration.
Investigating the association between COVID-19 vaccination and care home outbreak frequency and duration.
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DOI：
10.1016/j.puhe.2021.12.010
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发表时间：
2022-03
期刊：
影响因子：
5.2
通讯作者：
O'Reilly D
中科院分区：
文献类型：
--
作者：
Bradley DT;Murphy S;McWilliams P;Arnold S;Lavery S;Murphy J;de Lusignan S;Hobbs R;Tsang RSM;Akbari A;Torabi F;Beggs J;Chuter A;Shi T;Vasileiou E;Robertson C;Sheikh A;Reid H;O'Reilly D
2020 年底，许多国家启动了针对 SARS-CoV-2 的疫苗接种计划。公共卫生当局的目标是预防和阻止社会护理机构中传染病的爆发。我们的目的是调查疫苗接种计划的推出与北爱尔兰 (NI) COVID-19 爆发的频率和持续时间之间的关联。我们利用常规可用的国家数据进行了一项生态研究。我们使用泊松回归来衡量疗养院中 RT-PCR 确诊的 COVID-19 爆发数量之间的关系，并作为社区 COVID-19 患病率的衡量标准，国家统计局 COVID-19 感染调查估计了北卡罗来纳州 COVID-19 检测呈阳性的人数。我们估计了这种关系的变化，并估计了在没有疫苗接种计划的情况下疗养院爆发的预期数量。 Cox 比例风险模型估计了已确认的 COVID-19 护理院爆发关闭的风险比。引入疫苗接种计划后，疗养院疫情比预期减少了三分之二，从 2020 年 12 月 7 日至 2021 年 10 月 28 日期间预计的 1625 起 COVID-19 疫情（95% 预测区间 1553-1694）减少到观察到的 501 起。假设免疫有 21 天的滞后，我们估计疫情关闭的调整后风险比为 2.53。这些发现描述了疫苗接种与北爱尔兰护理院爆发频率和持续时间减少之间的关系。这表明接种疫苗后，社会护理机构中 COVID-19 造成的伤害和破坏可能会减少。未来的研究需要使用疗养院居民的个人水平数据来调查疫苗的有效性及其效果的持续时间。
At the end of 2020, many countries commenced a vaccination programme against SARS-CoV-2. Public health authorities aim to prevent and interrupt outbreaks of infectious disease in social care settings. We aimed to investigate the association between the introduction of the vaccination programme and the frequency and duration of COVID-19 outbreaks in Northern Ireland (NI). We undertook an ecological study using routinely available national data. We used Poisson regression to measure the relationship between the number of RT-PCR confirmed COVID-19 outbreaks in care homes, and as a measure of community COVID-19 prevalence, the Office for National Statistics COVID-19 Infection Survey estimated the number of people testing positive for COVID-19 in NI. We estimated the change in this relationship and estimated the expected number of care home outbreaks in the absence of the vaccination programme. A Cox proportional hazards model estimated the hazard ratio of a confirmed COVID-19 care home outbreak closure. Care home outbreaks reduced by two-thirds compared to expected following the introduction of the vaccination programme, from a projected 1625 COVID-19 outbreaks (95% prediction interval 1553–1694) between 7 December 2020 and 28 October 2021 to an observed 501. We estimated an adjusted hazard ratio of 2.53 of the outbreak closure assuming a 21-day lag for immunity. These findings describe the association of the vaccination with a reduction in outbreak frequency and duration across NI care homes. This indicates probable reduced harm and disruption from COVID-19 in social care settings following vaccination. Future research using individual level data from care home residents will be needed to investigate the effectiveness of the vaccines and the duration of their effects.
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DOI：
10.1016/s0140-6736(21)00677-2
发表时间：
2021-05-01
期刊：
Lancet (London, England)
影响因子：
--
作者：
Vasileiou E;Simpson CR;Shi T;Kerr S;Agrawal U;Akbari A;Bedston S;Beggs J;Bradley D;Chuter A;de Lusignan S;Docherty AB;Ford D;Hobbs FR;Joy M;Katikireddi SV;Marple J;McCowan C;McGagh D;McMenamin J;Moore E;Murray JL;Pan J;Ritchie L;Shah SA;Stock S;Torabi F;Tsang RS;Wood R;Woolhouse M;Robertson C;Sheikh A
通讯作者：
Sheikh A
DOI：
10.1016/s2666-7568(20)30012-x
发表时间：
2020-10
期刊：
The lancet. Healthy longevity
影响因子：
--
作者：
Burton JK;Bayne G;Evans C;Garbe F;Gorman D;Honhold N;McCormick D;Othieno R;Stevenson JE;Swietlik S;Templeton KE;Tranter M;Willocks L;Guthrie B
通讯作者：
Guthrie B
影响因子：
9.3
作者：
Morciano M;Stokes J;Kontopantelis E;Hall I;Turner AJ
通讯作者：
Turner AJ
影响因子：
6.7
作者：
Housley G;Lewis S;Usman A;Gordon AL;Shaw DE
通讯作者：
Shaw DE
DOI：
10.1016/j.lanepe.2021.100295
发表时间：
2022-03
期刊：
The Lancet regional health. Europe
影响因子：
--
作者：
Schultze A;Nightingale E;Evans D;Hulme W;Rosello A;Bates C;Cockburn J;MacKenna B;Curtis HJ;Morton CE;Croker R;Bacon S;McDonald HI;Rentsch CT;Bhaskaran K;Mathur R;Tomlinson LA;Williamson EJ;Forbes H;Tazare J;Grint D;Walker AJ;Inglesby P;DeVito NJ;Mehrkar A;Hickman G;Davy S;Ward T;Fisher L;Green AC;Wing K;Wong AY;McManus R;Parry J;Hester F;Harper S;Evans SJ;Douglas IJ;Smeeth L;Eggo RM;Goldacre B;Leon DA
通讯作者：
Leon DA