Familial hyperthyroxinemia due to abnormal thyroid hormone binding.
Familial hyperthyroxinemia due to abnormal thyroid hormone binding.
复制标题
由于甲状腺激素结合异常导致的家族性高甲状腺素血症。
DOI：
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发表时间：
1982
影响因子：
39.2
通讯作者：
B. Premachandra
中科院分区：
文献类型：
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作者：
J. Silverberg;B. Premachandra
患者血清总甲状腺素（T4）、游离甲状腺素（游离T4）、游离T4指数和T4/甲状腺素结合球蛋白比值升高。血清三碘甲状腺原氨酸（T3）以及促甲状腺激素对促甲状腺激素释放激素的反应正常，与临床甲状腺功能正常状态一致。血清总T4、游离T4指数和T4/甲状腺素结合球蛋白升高的基础是甲状腺激素与白蛋白的结合异常增强，或通过纸电泳系统测定的迁移率与白蛋白相似的异常蛋白质迁移。在患者家族的几个成员中也观察到异常的T4蛋白结合，表明该病症是家族性的。一种新型的血清T4蛋白结合异常导致高甲状腺素血症可能错误地提示甲状腺功能正常的受试者的甲状腺毒症。
A patient had an elevated serum total thyroxine (T4) free thyroxine (free T4), free T4 index, and T4/thyroxine-binding globulin ratio. The serum triiodothyronine (T3), as well as the thyrotrophin response to thyrotrophin-releasing hormone was normal and consistent with the clinical euthyroid status. The basis for the elevated serum total T4, free T4 index, and T4/thyroxine binding globulin is the abnormally enhanced binding of thyroid hormone by albumin, or by an anomalous protein migrating with a mobility similar to albumin as determined in paper electrophoretic systems. The abnormal T4 protein binding was also seen in several members of the patient's family indicating that the condition was familial. A new type of serum T4 protein binding abnormality that results in hyperthyroxinemia may falsely indicate thyrotoxicosis in clinically euthyroid subjects.