Targeting memory T cell metabolism to improve immunity.
Targeting memory T cell metabolism to improve immunity.
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DOI：
10.1172/jci148546
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发表时间：
2022-01-04
期刊：
影响因子：
--
通讯作者：
Pearce EL
中科院分区：
文献类型：
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作者：
Corrado M;Pearce EL
疫苗接种通过激活病原体特异性免疫细胞以及促进针对疫苗特异性病原体的持久性免疫记忆的形成来提供疾病防护。当前的疫苗方案往往基于急性免疫反应的效率，而不一定基于记忆细胞的产生，部分原因是有效免疫记忆形成的潜在机制仍未完全被理解。这篇综述描述了在定义记忆T细胞代谢方面的最新进展，以及在受线粒体疾病或代谢综合征影响的患者中这些细胞的代谢可能如何改变，这些患者对反复感染的易感性更高，疫苗接种失败率也更高。它还讨论了这种新的理解如何能够丰富我们对免疫记忆、疫苗研发和癌症免疫疗法的思考方式。
Vaccination affords protection from disease by activating pathogen-specific immune cells and facilitating the development of persistent immunologic memory toward the vaccine-specific pathogen. Current vaccine regimens are often based on the efficiency of the acute immune response, and not necessarily on the generation of memory cells, in part because the mechanisms underlying the development of efficient immune memory remain incompletely understood. This Review describes recent advances in defining memory T cell metabolism and how metabolism of these cells might be altered in patients affected by mitochondrial diseases or metabolic syndrome, who show higher susceptibility to recurrent infections and higher rates of vaccine failure. It discusses how this new understanding could add to the way we think about immunologic memory, vaccine development, and cancer immunotherapy.